Common Sense Ways to Deal With Coronavirus 
By Walter Sorochan Emeritus Professor San Diego State University

Posted January 30, 2021;  Disclaimer The information presented here is for informative and educational purposes only and is not intended as curative or prescriptive advice. The statements of this web-site have not been evaluated by the United States Food and Drug Administration (FDA). Nothing stated here should be considered as medical advice for dealing with a given problem, or to diagnose / treat / prevent / cure any disease.

With government agencies and pharmaceutical companies pumping so much money and energy into finding a solution for COVID-19, this article discuses a simple, supposedly safe, and cost-effective option that could help people at home and their work be healthy amidst the pandemic. I was stunned .... shocked to discover that there is another way than just vaccines to deal with coronavirus pandemics.

For over a year, the world has been under attack by COVID-19 (coronavirus disease 2019) causing a pandemic. The world has been in chaos and the scientific community and political leaders have been unable to quickly and effectively deal with a world wide pandemic. World leaders have put their hope in developing a vaccine. But access and distribution difficulties are continuing to disrupt bringing the pandemic under control. We are still in clinical trials with vaccines Madera and Pfizer that have been temporarily approved. All day long attention on TV is focused on vaccine availability and distribution while other possible treatments have faltered.  1  

There is an urgent unmet need to provide an easy-to-produce, affordable medicine to prevent transmission and provide early treatment for this disease. The nasal cavity and the rhinopharynx [back of throat and voicebox] are the sites where SARS-CoV-2 first attacks the body. Therefore, a nasal spray may be a suitable medication for this purpose.  2    But a nasal spray is not being discussed on TV or newspapers at this time.

Thomas Higgins from University of Louisville and colleagues summarize findings for the potential role of studying topical intranasal delivery of drugs and agents known to have antiviral properties in SARS-CoV-2.  3 

To understand the rational of how viruses affect the body, we need to know where viruses first enter the body. Viruses are first inhaled through the nose, nasal passages into the sinuses that have mucus, spreads slowly its way through the throat, the voice box, bronchial tubes and eventually into the lungs where it disrupts breathing.   4 

Sanchez-Gonzalez pointed out that the CDC guidelines provide little direction for treatment in the early stages of COVID-19. However, it is in the early stages of treatment, in the nose, that is very important time to have treatment in order to reduce serious, long-lasting effects. Washing the nose with Nasal Spray is a crucial step in staying healthy and curbing COVID-19’s progression into later stages.    5

The chart below, Three Stages of COVID-19, illustrates how coronavirus affects and attacks the body in three stages:  6 

corona 3 stages

Centers for Disease Control   7   medical experts have focused recommended treatment of prevention using masks, social distancing and hand washing. These preventive measures have certainly helped to slow the spread of coronavirus. But the public's lacking of discipline and understanding has not helped.

In the chart above, researchers argue hat there is a need to treat COVID-19 in its early stages to prevent potential damage to the lungs. In initial Stage 1, the virus is first inhaled into the nose and nostrils and probably the sinuses below the eyes. Stage 2 occurs when the virus infects the throat and Stage 3 happens when the virus lodges in the lungs. This information, how the virus travels in the body, helps scientists understand how to fight coronavirus.

The shortcomings of vaccines are difficult, such as making enough vaccines rapidly, distributing these, not knowing whether the vaccine will stop all mutants and strains of COVID-19 and not knowing how long the vaccination will actually last. So having another medical aid would be of great help.

Treatment through the nose isn’t a novel or unproven method. Here are a few studies, articles, and links that provide evidence that there is another way to help slow down COVID-19.

Many medical researchers have found that during the first days of the disease, the virus is located mainly in the nasal cavity and the nasopharynx [nose-throat area]. Research showed that high viral load and long virus-shedding period was associated with COVID-19. Numerous researchers found that using antiviral nasal sprays reduced viral infection in the nose, thus slowing the spread of viral disease into the lungs.   8   9    It is in stage 1 that medical scientists realized that if they can trap the virus in the nose, disable it for a while, then they can slow down or stop the spread of the virus. This is the strategy being used to develop nasal sprays.

This is the approach Dr. Richard Boucher and his researchers at University of North Carolina at Chapel Hill took:  "If the nose is the dominant initial site from which lung infections are seeded, then… nasal irrigation or antiviral nasal sprays, could be beneficial." 90% of viral load is in the nose.“  10 

Another researcher, Dr Lon Jones from Plainville, Texas, who discovered the sugar xylitol for nasal spray, suggests washing your nose with xylitol to subdue COVID-19. ‘Your nasal passages are a primary defense against viruses, especially if the nose is working optimally…. xylitol-saline washes and hydrates the nasal mucosa to assist the immune system in cleaning out bacteria viruses, and pollutants before they have a chance to infiltrate the lungs.’  11  12  13  

Dr. Richard Moakes and his researchers at University of Birmingham, Alabama, have developed a nasal spray which can stop Covid-19 in its tracks for two days and claim it could be sold in pharmacies in the summer of 2021. Moakes says his formula could help bring the United Kingdom [UK] out of crippling lockdown restrictions.   14  15  

Moakes' nasal spray is already widely approved by regulatory bodies in the United Kingdom [UK], Europe and the US. The materials are already used in medical devices, medicines and even food products, and it works by capturing coronavirus in the nose and trapping it in a coating.

AeroNab, has already been formulated by researchers at the University of California, San Francisco. This nose spray works like a nebulizer, functions much like an antibody and fends off coronavirus. The researchers are now working to get it clinically tested and manufactured. AeroNabs prevents infection by capturing the virus in the nose and covering it with a coating from which the virus cannot escape. This would make it safe for someone to exhale near another person as the virus would be inactive and harmless. Lab experiments showed that the spray prevented an infection from spreading for up to 48 hours.   16 

Federal Trade Commission [FTC] acting associate director Serena Viswanathanon, on July 29, 2020, accused the maker of over the counter nasal spray, Xlear Sinus Care, based in Utah, of unfair advertizing.   17   This is an 'hush-hush' accusation in spite of two university studies showing that this nasal spray works.

Other scientists stated that they were inspired by nanobodies, which are like antibodies found in llamas and camels. “Though nanobodies function much like the antibodies found in the human immune system, nanobodies offer a number of unique advantages for effective therapeutics against SARS-CoV-2,” said co-inventor Aashish Manglik, MD, Ph.D., an assistant professor of pharmaceutical chemistry.   18    

Manglik and authors explained in the report that they developed “single-domain antibodies (nanobodies) that potently disrupt the interaction between the SARS-CoV-2 Spike and ACE2." They were able to create synthetic nanobodies in a yeast surface and found that the nanobodies bound to the spikes and blocked the ACE2 interaction, thus blocking the virus from further invading the host.

The investigators explained in the news release that the most potent nanobodies act not only like a sheath surrounding the spike receptors, but also like a "molecular mousetrap, clamping down on spike in its closed, inactive state, which adds an additional layer of protection against the spike–ACE2 interactions that lead to infection.”

Additional Nasal spray Research:

At Utah State University’s Institute of Antiviral Research, Jonna Westover, Ph.D. and her team studied the affect a xylitol saline solution had on COVID19:

Results: The study compared the effect of four different saline solutions with xylitol against chlorhexidine and ethanol, with water as a control. The four different solutions with xylitol were:   19   

The results were astounding. Each of the four saline and xylitol solutions significantly reduced the virus to ‘an undetectable amount.’

On Dec 21, 2020, researchers from Northwestern and Utah State Universities reported testing effectiveness of over-the-counter nasal spray, Xlear Sinus Care, against cultures of SARS-CoV-2 virus causing COVID-19. Ingredients of the spray included 11 % xylitol [sweetener] that reduced severity of infections by preventing virus attachments to the core protein cell wall; a .2 % grapefruit seed extract [GSE] reduced viral load and .85 % saline prevented virus attachment to the core protein on the cell wall.  After 25 minutes of contact time, the amount of active virus was dramatically reduced by GSE and neutralized by xylitol.  20    

Another study at Larkin Community Hospital in South Miami, Florida, showed that nasal spray effectively helped COVID patients fight symptoms.  21 

Dr. Lisa Rohan, a professor at the University of Pittsburgh School of Pharmacy and Magee-Women's Research Institute & Foundation, is leading the nasal spray project with collaborators at the University of Louisville. “This is not like a vaccine,” says Rohan. “This will be more of an on-demand type product. You’d be spraying it daily in each nostril. If you’re going to the grocery store, or to work, it would hopefully provide protection while you’re on your shift. “We’re looking at a product for first responders and healthcare workers so that they would have some means of protection.” The nasal spray contains a molecule called Q-griffiths that has antiviral properties.   22   

 There is obviously a lot of interest in nasal sprays by physicians in hospitals to develop a safe deterrent to stop CONID-19 throughout the world; for example a  company in Australia has developed a nasal spray INNA-051.

There are other common sense alternatives to nasal sprays:

Better hygiene: Wearing face masks, washing hands, and social distancing when in public. These personal hygienic practices have not been successful in stopping the spread of coronavirus; but they do help.

Cleaning Nasal passages: Use a neti Pot to clean or irrigate sinuses and nasal passages.  Doctor Gustavo Ferrer of Aventura Hospital and Medical Center in Avrntura, Florida, pointed out that cleaning the nose and mucus in the sinuses means less virus and less infection. The idea is to trap the virus in the nose before it has time to spread.  23  24   

Frank reported that Hou et al recently demonstrated that SARS-CoV-2 initially infects cilliary cells of the nasal mucosa and that this may represent the dominant initial site for infection. The virus then spreads via the nasal-oropharyngeal axis to the lungs through micro-aspiration, leading to the damaging respiratory infections seen in COVID-19. The variable severity witnessed during the COVID-19 pandemic may be due to variable transmission of SARS-CoV-2 from the nasal cavity to the lungs in patients who test positive for the virus. Therefore, transnasal viral inactivation may not only prevent person-to-person spread of SARS-CoV-2, but may also diminish the severity of disease in patients by limiting spread and decreasing viral load delivered to the lungs. Povidone-iodine [antiseptic used before and after surgery] nasal irrigation may be beneficial for the population at large as an adjunct to mask usage as a means of virus mitigation.  25    

Williams reports that weekly nasal spray could prevent 96 per cent of coronavirus infections.   26 

Nutrient Impact on COVID-19: Zhang Lei proposed a number of nutrients to minimize the spread of conronavirus in China in February, 2020. These included:  27 

Vitamin K: The Atlanta Journal-Constitution reported that a study at the Center for Clinical Research and Prevention at Frederiksberg Hospital in Denmark compared 138 hospitalized COVID-19 patients with those of 140 healthy people. Results showed that hospitalized COVID patients had vitamin K levels that were half of the healthy control group. 4-3 subjects who died of coronavirus had vitamin K levels that were even lower. Vitamin K helps the body maintain healthy blood vessels and activates enzymes that protect lung tissue. Those with low vitamin levels are hit hardest by illness. Vitamin K rich foods, including lettuce, kale and spinach, provide better sources of vitamin K than supplements.  28    [Mack]

Researcher Allan Linneberg, MD, pointed out that vitamin K helps your body maintain healthy blood vessels and activates enzymes that help protect lung tissue, which are two major organs that are seriously affected by the respiratory virus. "When these are not activated, the lungs become poorer and can explain why COVID-19 patients with low vitamin levels are hit hard by the illness."  29  

Vitamin D: The Sept 2020 Journal of the American Medical Association reported that vitamin D deficiency increases your risk of testing positive for coronavirus by nearly 80 %.   30    In another study, Aponte and Palacios reviewed vitamin D deficiency in children worldwide and noted that vitamin D deficiency is world wide, implicating susceptibility to coronavirus.   31  

Vitamin C: Researchers at University of Georgia, Augusta, linked low levels of vitamin C to high risk to coronavirus infection.  32    Chapman pointed out that more than 100 studies showed that vitamin C could slash the deaths of patients in intensive care units by 68%. Covid-19 patients have such low vitamin C levels that  infections induce scurvy and death.  33  

 Vitamin B-1: Researchers from College of Food and Agriculture at United Arab Emirates University found that vitamin B-1 improves immune function, reduces risk of type-2 diabetes and can maintain healthy blood oxygen levels .... all of which enhance dealing with coronavirus.   34 

Flavonoids: "Flavonoids are an important class of natural products and have several subgroups, which include chalcones, flavones, flavonols, and isoflavones. Flavonoids have many functions besides antioxidant effects and they also have antiviral abilities. Shimizu et al had found that flavonoids from Pterogyne Nitens could inhibit the entry of the hepatitis C Virus. Jo et al had suggested that the anti‐coronavirus activity of some flavonoids (Herbacetin, rhoifolin and pectolinarin) was due to the inhibition of 3C like protease (3CLpro). Other flavonoids (Herbacetin, isobavachalcone, quercetin 3‐β‐d‐glucoside, and helichrysetin) were also found to be able to block the enzymatic activity of MERS‐CoV/3CLpro. Moreover, Ryu et al had reported that biflavonoids from Torreya nucifera also brought inhibition effect of SARS‐CoV/3CL (pro)."   35 

Iodine: Samantha Frank and her researchers at the University of Connecticut School of Medicine published an article in JAMA Otolaryngol Head Neck Surgery, 2020, that demonstrated rapid, complete inactivation of SARS-CoV-2 by concentrations of Povidone-iodine nasal antiseptic solutions [PVP-I] as low as 0.5% after 15 seconds of contact. This study demonstrates that a contact time of 15 seconds is sufficient for viral inactivation.   36    It was David Derry, MD, who pointed out in 2008 that iodine used in small doses kill viruses.  37 

Zinc:  According to a study in Spain ,March-April, 2020, COVID patients who had higher levels of zinc in their blood had a higher chance of surviving their disease than those who had much lower levels. Zinc bolsters the immune system that has an anti-inflammatory effect.  38 

Omega-3 fatty acid: According to a new study conducted by researchers at the Fatty Acid Research Institute (FARI) and Cedars-Sinai Medical Centers of Los Angeles and Orange County, having adequate levels of omega-3 fatty acids in your blood could keep you from developing severe COVID:

According to a study in January 20, 2021 issue of Journal Prostaglandins, Leukotrienew and Essential Fatty Acids, researchers at Fatty Acid Research institute [FARI] and Cedars-Sinai Medical Centers of Los Angeles and Orange County, adequate amounts of omega-3 fatty acids in the blood can keep one from developing severe COVID. According to lead author, Arash Asher, those with the highest levels of omega-3 fatty acids in the blood were at reduced risk of dying from COVID. They were 75 % less likely to die than patients with lower circulating omega-3 levels.  39    

Nano-colloidal silver solution This solution of silver 10 ppm is safe and kills bacteria and viruses instantly with no side-effects. Silver ruptures the outer skin of the virus, acts as a catalyst and disables the inner contents, including destruction of the viral DNA.   40 

Conclusion:  Most people in the world, including United States, Canada and Europe, are having difficulty getting vaccinated now.  It may take several years more before everyone on this plant is vaccinated and coronavirus is brought under control. But most do not have to wait that long. Nasal sprays are able to neutralize coronavirus in the nose area for two days. Further research may extend the length of viral incapacity. Although safe nasal sprays are already being marketed in several countries,   41  clinical trials for nasal sprays are in early stages.

Even when you might use nasal spray, you really do not know if it is effective and working. You have no test to verify its use. So do not assume anything at this time when clinical trials are missing. There is no guarantee that any approach will work!

Before administering any covid-19 therapy, you should evaluate the nutritional status before getting a vaccine or nasal spray.   42   We do not know what affect a nasal spray would have on a person prior to getting a vaccination, so it would be prudent to avoid using nasal spray before and during vaccination. If vaccines work then nasal sprays should not be needed. Current nasal sprays are promising but not a slam dunk at this time and we need more research.

It is morally wrong for governments to deny access to nasal sprays when there is so much commotion with vaccines.

Although the potential of nasal sprays is good news for the general public, use caution at this time.

Then there are inexpensive and readily available vitamins and minerals that can also help!

But why is all this information about nasal sprays and nutrients being covered up by our own government? Why is there no reporting of this on TV?

The hand-writing is on the wall. Coronavirus healers are discovering inexpensive natural nutrient therapies for coronavirus. "Food is man's best medicine."

References:

1 Zimmer Carl, "How the search for covid-19 treatments faltered while vaccines sped ahead," The New York Times, January 30, 2021.  Zimmer: Virus treatments faltered 2021

2 Bansal Shruti, etla, "Iota-carrageenan and Xylitol Inhibit Sars-CoV-2 in Cell Culture," University of Tennessee Anti-Viral Study, August 21, 2020.  Basal: Nasal spray early treatment for coronavirus 2020

3 Higgins, Thomas S., et. la, "Intranasal Antiviral Drug Delivery and Coronavirus Disease (COVID-19): A state of the art review," Otolaryngology-Head and Neck Surgery, July 14, 2020.,"  Higgins: Intranasaldrug delivery 2020

4 Bansal (2020)

5 Sanchez-Gonzalez Marcos A. , Dave Moskowitz, Priya D. Issuree George Yatzkan, Syed A. A. Rizvi, and Kenneth Day, "Information you should know about covid-19," Common Sense Medicine, Infect, Chemother. 2020; 52:e31. Published online Jul 15, 2020.  Sanchez-Gonzalez: treat virus early 2020

6 Sanchez-Gonzalez (2020)

7 Viswanathan Serena,  "FTC warning letter to Xlear Sinus Care," Federal Trade Commission, July 29, 2020.  FTC: letter to Xlear Sinus Care 2020

8 Bansal (2020)

9 Hou Yixuan J., and others, "SARS-CoV-2 Reverse genetics reveal a variable infection gradient in the respiratory tract, Cell, Volume 182, Issue 2, pp 429-446, E14, July 23, 2020.  Hao: Nasal susceptibility to virus 2020

10 Viswanathan Serena (2020)

10 Viswanathan Serena (2020)

11 Jones Lon, Asthma and allergy solution that works for COVID-19: The powerful natural prescription for respiratory health during the coronavirus pandemic, Amazon Book,September 1, 2020.  Jones: nasal spray for COVID-19 2020

12 Steinman David, "Experienced antibodies know how to subdue COVID-19," The Good Men Project, April 11, 2020  Steinman: Subdueing COVIC-19 2020

13 Walker William, "Nasal spray that can stop coronavirus infections for days could be in shops by summer," ChronicleLive, January 26, 2021.  Walker: Nasal spray stops COVID-19 2021

14 Mack Zachary, "This over-the-counter medication can kill COVID, study says," BestLife, January 27, 2021.  Mack: Over-counter kills virus 2021

15 Mack

16 McGorry Amy, "Antiviral nasal spray may fight coronavirus, study finds," Fox News, August 12, 2020.  McGorry: AeroNabs nasal spray fights corona 2020

17 Viswanathan Serena (2020)

18 McGorry (2020)

19 Viswanathan Serena (2020)

20 Mack (2021)

21 Mack (2021)

22 Machosky Michael, "A nasal spray that prevents COVID-19? Pitt researchers awarded grants for urgent COVID-19 research," NexPittsburgh, May 4, 2020.  Machosky: Research for nasal spray 2020

23 Mack (2021)

24 Sanchez-Gonzalez (2020)

25 Frank Samantha, Seth M. Brown, Joseph A. Capriotti, Jonna B. Westover, "In Vitro Efficacy of a Povidone-Iodine Nasal Antiseptic for Rapid Inactivation of SARS-CoV-2," Journal of American Medical Association, September 17, 2020.  Frank: iodine inactivation coronavirus 2020

26 Williams Terri-Ann, "Weekly nasal spray could prevent 96 per cent of coronavirus infections, Public Health England (PHE) has claimed," The Sun, September 28, 2020.  Williams: Nasal sprat prevents 96% of viral infections 2020

27 Lei Zhang and Yunhui, "Potential interventions for novel coronavirus in China: A systemic review," Journal of medical Virology, February 13, 2020.  Lei: Interventions of coronavirus 2020

28 Mack Zachary, "Lacking this vitamin could put you at risk of severe COVID, new study says," BestLife, January 8, 2021.  Mack: Lacking Vit K increases virus risk

29 Mack (2021)

30 Mack (2021)

31 Aponte Rhaisa and Cristina Palacios, "Vitamin D for prevention of respiratory tract infections, World Heal th organization, June, 2017.  Aponte: Vit D and repiratory infections 2017

32 Mack (2021)

33 Chapman, Adam, "Coronavirus update: Vitamin C could save the lives of those severely affected by Covid-19," Nutrients, December 8, 2020. Chapman: Vitamin C saves infected covid-19 patients 2020

34 Mack (2021)

35 Lei (2020)

36 Frank (2020)

37 Derry David, "Iodine: the forgotten weapon against influenza viruses," Thyroid Science, 4(9):R1-5, September 2, 2009.  Derry: Iodine fights viruses 2009

38 Mack (2021)

39 Crow Sarah, " If you have this in your blood, you may be safe from COVID, study says," BestLife, January 26, 2021.  Crow: Omega-3 & coronavirus 2021

40 Sorochan Walter, "Features of best silver?" Silver for me, December 7, 2014.  Sorochan: Nano colloidal Silver kills viruses 2014

41 Bansal (2020)

42 Lei (2020)