By Walter Posted July 13, 2010; Updated October 19, 2021. Disclaimer The information presented here is for informative and educational purposes only and is not intended as curative or prescriptive advice. Understanding how the body makes its own immune enhancing system Most of us are familiar with vaccines and that immunizations help prevent influenza and diseases. But that may be the extent of our knowledge about the immune system and how it really works. This article shares information about how our immune system can be supercharged with a new supplement called GliSODin.But first, a brief background about why we need an immune system and then how an Superoxide Dismutase [ SOD ] helps to make the immune system work. Our immune system is part of our body's need to get rid of wastes. Oxidants are waste products formed when oxygen is used to metabolize food and make energy. These oxidants are also referred to as free radicals because they are very unstable and circulate in the body looking to attach to body cells, in an effort to stabilize. An excess of free radicals can interfere with normal body processes, such as disrupting our protection system, the immune system. Alone or in combination with primary factors, free radicals are involved in the cause of hundreds of diseases. To avoid free radical build up, babies are born with the antioxidant ability to fight and get rid of free radicals. These early life antioxidants are referred to as Superoxide Dismutase or SOD. Superoxide dismutase has been found in almost all organisms living in the presence of oxygen, including some anaerobic bacteria. In humans, three forms of superoxide dismutase are present. SOD1 is located in the cytoplasm, SOD2 in the mitochondria and SOD3 is extracellular. The physiological importance of SODs is illustrated by the severe pathologies evident in mice genetically engineered to lack these enzymes. Mice lacking SOD2 die several days after birth, amidst massive oxidative stress. Mice lacking SOD1 develop a wide range of pathologies, including hepatocellular carcinoma, an acceleration of age-related muscle mass loss, an earlier incidence of cataracts and a reduced lifespan. Mice lacking SOD3 do not show any obvious defects and exhibit a normal lifespan. All three are essential for human well-being and staying alive! SOD is made at birth but rapidly decreases with age. Your body starts pumping SOD into your system in the first few hours of baby life. It’s absolutely necessary for survival. Unfortunately, this capability to synthesize SOD dissipates early in life, so that as we grow older we have less and less ability to synthesize SOD. The main antioxidants created by the body, SOD, is the first line of defense against the free radical substance called superoxide. In absence of the first defensive line of SOD, we also have a backup system of getting antioxidants from eating foods rich in SOD, like broccoli, cabbage, greens, ground flax seed, melons and fruits. Unfortunately, foods provide such a weak second line of defense against free radicals that free radicals can over accumulate and disrupt [ stress ] our immune system. The immune system is particularly compromised by smoking, pollution, exposure to sunlight [ UV radiation ], infection, processed foods, sugars and aging; resulting in "oxidative stress." [ a condition where more oxygen wastes or free radicals accumulate than can be removed by antioxidants from the body, causing stress on cells to survive. So, as children, teenagers and adults, we need SOD for survival and staying healthy. Unfortunately the supplement SOD is immediately destroyed by stomach acids when ingested orally. Commonly available SOD supplements are obviously ineffective and do not work. Glisodin Media Ctr. article is no longer active. Scientists in France overcame this problem by wrapping SOD in a protective film or capsule wheat protein [ Gliadin ] that protects SOD from being broken down by stomach acids. Supplementing with this new supplement, GliSODin®, now allows your body to absorb SOD without destruction. Glisodin Media Ctr. article no longer active.
GliSODin is an "enzyme of life" that is credited with being a natural body anti-oxidant that prolongs life, enhances immunity, prevents diseases and protects against sunburn. SOD Background: SOD, dubbed the “enzyme of life” on discovery in 1968, is the first antioxidant mobilized by the cell as defense against oxidative stress. The enzyme reacts with the superoxide ion and turns it into hydrogen peroxide (H2O2). This is then catabolized by catalase and glutathione peroxidase to produce molecular oxygen (O2) and water (H2O). Glisodin organization info: article no longer active. Figure: Role of antioxidant enzymes in the inactivation of the superoxide ion.
Glisodin organization info: article is no longer active. These antioxidant [ SOD ] enzymes have a distinct advantage over the antioxidants consumed from the diet or nutritional supplements, like the vitamins A, C, and E, carotenoids, and thiols; since the SOD enzymes are biological catalysts, rapidly and repeatedly reducing reactive oxygen species without being consumed themselves. By reacting early in the process, the antioxidant enzymes can minimize the potentially-harmful oxidation of a range of biological molecules. Glisodin organization info: article is no longer active. Kinds of Antioxidants: Three first line intracellular antioxidant enzymes are Super Oxide Dismutase [ SOD ], Catalase (Cat) and Glutathione peroxidase (GPx). The SOD enzyme system exists in three different forms based on different cofactor minerals: zinc, copper and manganese, that aid in forming the three SOD enzymes. Figure on the right above illustrates these concepts about glisodin, andioxidants and SOD. A Primary Antioxidant SOD Enzyme recycles itself again and again, quenching many thousands of free radicals at their initial source. By contrast, Secondary Antioxidants such as those consumed in foods and supplements quench only ONE free radical for each antioxidant. Free Radicals and SOD SOD, a natural body enzyme and an antioxidant, has the power to intercept many seemingly-unrelated disease processes. It does this by neutralizing the many thousands of toxic free radicals,, referred to as superoxides. Because superoxide is toxic, nearly all organisms living in the presence of oxygen contain isoforms of the superoxide scavenging enzyme, superoxide dismutase, or SOD. SOD is an extremely efficient enzyme; it catalyzes the neutralization of superoxide nearly as fast as the two can diffuse together spontaneously in solution. By far the greatest source of superoxide generation in cells is the mitochondria. It is in the mitochondria that oxygen breaks down glucose to release ATP as energy for the body. This process explains why SOD may help athletes to recuperate faster from exercise fatigue. Oxygen utilization in ‘burning’ glucose to produce ATP is not 100% efficient and around 2-4% of oxygen used in the mitochondria ‘leaks’ out and is converted to the free radical Superoxide. SOD, and GliSODin in particular, regulate [ neutralize ] superoxide at its mitrochondria source. Doing the neutalizing of superoxide at its source saves other processes from doing it downstream in an inefficient manner that can result in free radicals piling up and inhibiting the metabolic processes and destroying healthy cells. wiki superoxides Thus, thanks to SOD,nbsp; the body can make its own system of antioxidants to get rid of free radicals. Unfortunately, this capability to do so erodes early in life, so that as we grow older we have less and less ability to do so. The main antioxidant, SOD, is the first line defense against the free radical substance superoxide. Eating foods rich in SOD, like broccoli, cabbage, greens, melons and fruits, provides a much weaker second line of defense.
Research done on mice and human volunteers has validated the effectiveness and safety of using GliSODin®:
These and other studies Glisodin Media Ctr. article is no longer active. confirm that GliSODin® works. New research opens the door for further discoveries about how SOD and its related enzymes help promote good health. Houghton article about GliSODin Australia is no longer available. The new research about GliSODin® indicates that those using Glisodin get 800 percent more sun protection . . . completely naturally.
More Observational Studies on the Effectiveness of Super Glisodin
Pharmacokinetic Studies and Dosage Considerations Pharmacokinetic studies to determine the optimal dosage showed that one 250mg capsule begins to up-regulate endogenous synthesis of SOD around 3 hours after consumption. A steep increase over the next 3 hours reaches a maximum threshold which is maintained at this level over approximately 6 hours, after which the enzyme levels fall away. It is apparent that after ingestion of one GliSODin capsule, SOD levels are elevated after 3 hours and remain so for a further 9 hours [3 Vouldoukis ]. Assumingly, dosing of 2 capsules daily approximately 12 hours apart should provide almost continuous induction of SOD. Furthermore, continuous dosing of 2 capsules daily as described above gradually increases the maximal threshold to a peak reached at around 28 days. A significant benefit of GliSODin over any of the SOD-mimetic drugs lies in its ability to substantially upregulate all 3 Antioxidant Enzymes, Superoxide Dismutase, Glutathione peroxidase and Catalase. Vouldoukis article about validation of SOD is no longer active. In this way, the function of GliSODin more closely approximates that of more youthful human Antioxidant Enzyme activity. Dosage: There is some confusion about the best Glisodin dosage; suggestions ranging between 100 to 300IU per day; such as base dosage is equivalent to 100 IU of SOD per day. Vouldoukis pointed out earlier that a dosage of 250 IU per day maintained a high level of SOD for 12 hours. Ingesting a 250IU capsule every 12 hours would allow the immune system to activate its own catalytic action. GliSODin® is available in high potency as Super GliSODin, offering 250 mg in each vegetable capsule, 60 capsules per bottle; and as GliSODin, offering 100 mg in each vegetable capsule, 90 capsules per bottle. Dosage availability: This dosage may vary with merchants and capsule size. The suggested dosage per day is 250 IU of GliSODin®. Safety: GliSODin® is a completely vegetarian product that is well tolerated and is safe to consume. GliSODin® does contain wheat ingredient and a source of gluten. GliSODin® is not recommended for anyone with wheat or gluten sensitivity. You should have your health therapist monitor you while taking supplements. Conclusion: GliSODin® enhances the body's ability to tolerate sunlight by providing natural body antioxidants. But its importance to overall health has been overlooked by the medical and scientific communities. It provides a bolster of SOD the the human body so desperately needs. The SOD enzyme system, Super Oxide Dismutase (SOD), Catalase (Cat) and Glutathione peroxidase (GPx), are essential for human well-being and staying alive!
GliSODin is reported to be able to supercharge the body to make it's own antioxidants; referred to in general as SOD. These natural body SODs can be used many times catalytically to neutralize free radicals without the need to be replenished as food source antioxidants do. SOD and especially the supplement GliSODin® need to be given equal priority with amino acids, vitamin D, vitamin C, magnesium, amino acids, minerals and other nutrients and related co-factors in maintaining high immunity and preventing diseases. Kiefer article about SOD and aging is no longer active. Collectively these essential nutrients make up the future medical arsenal. Houghton article about GliSODin Australia no longer available. References [[1] Ceriello New Insights on Oxidative Stress and Diabetic Complications May lead to a ‘causal’ antioxidant therapy. Diabetes Care 26:1589-1596, 2003 [2] Catassi et al A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease American Journal Clinical Nutrition January, 2007. Vol. 85, No. 1, 160-166 [3] Vouldoukis, M. Conti, P. Krauss, C. Kamate, S. Blazquez, M. Tefit, D. Mazier, A. Calenda, B. Dugas. “Supplementation with gliadin-combined plant superoxide dismutase extracts promotes antioxidant defenses and protects against oxidative stress,” Phytotherapy Res Mar 1;18(12) (2004) 957-962 PMID: 15742357 Glisodin promotes antioxidation [4] Vouldoukis, D. Lacan, C. Kamate, P. Coste, A. Caldnda, D. Mazier, M. Conti, B. Dugas. “Antioxidant and anti-inflammatory properties of a Cucumis melon extract rich in superoxide dismutase activity,” J. Ethnopharmacology. 94 (2004) 67-75 PMID: 15261965 [5] Muth et al. Influence of an Orally Effective SOD on Hyperbaric Oxygen-related cell damage. Free Radical Research Volume 38, Number 9 / September, 2004. 927-932 [6] Bader et al. Influence of Vitamin C and E supplementation on Oxidative Stress Induced by Hyperbaric Oxygen in Healthy Men. Ann. Nutr. Metab. 2006;50:173-176 [7] Cloarec M et al. GliSODin, a vegetal SOD with Gliadin as preventive agent vs atherosclerosis, as confirmed with Ultrasound-B imaging. Cloarec article is no longer active. "Supplementation with GliSODin®, a vegetal SOD associated with gliadin, was effective in controlling the thickness of the carotid artery intima and media layers as measured by ultrasonography-B. We could demonstrate the preventive efficacy of GliSODin at a preclinical stage in subjects with risk factors of cardiovascular disease." [8] Crouse JR et al. The Meteor Trial JAMA 2007;297:1344-1353 [9] Brownlee, M. Banting Lecture 2004. The Pathobiology of Diabetic Complications: A Unifying Mechanism; DIABETES, VOL. 54, JUNE 2005; 1615-1625 [10] Naito T. et al. Reduction of diabetes-induced renal oxidative stress by a cantaloupe melon extract/gliadin biopolymers Oxykine in mice BioFactors Vol 23, Number 2 / 2005 [11] F. Marzatico, O. Pansarasa, L. Bertorelli, L. Somenzini, G. Della Valle. “Blood free radical antioxidant enzymes and lipid peroxides following long-distance and lactacidemic performances in highly-trained aerobic and sprint athletes,” Journal of Sports Medicine and Physical Fitness. (1997) Dec. 37(4) 235-9 PMID: 9509820 Antioxidants, free radical and oxidative stress: Antioxidants what are these? Bradley, Kyle, "Building bombproof immunity," Virgo Publishing, 2010, September 24, 2007. Bradley Building immunity article no loner active. Cloarec M., et la., "GliSODin, a vegetal sod with gliadin, as preventative agent vs. atherosclerosis, as confirmed with carotid ultrasound-B imaging," Eur Ann Allergy Clin Immunol., 2007 Feb;39(2):45-50. Glisodin preventing CVD Germano Carl, "Sun Protection from the Inside!" Millennium Biotechnologies Group Inc. Germono Sun protection from inside Glisodin,"Backgrounder," Glinsidin Media Center. Glisodin Media Ctr. article no longer active.
Glisodin is a nutritional supplement based on two constituents:
GliSODin® may provide significant protection, follow-up research study against UV radiation-induced skin changes Protection against sunlight "GliSODin supplementation resulted in an increase in the minimum exposure to UV rays necessary to produce skin burn. In particular, phototypes II required eight times greater exposure than that of the placebo." Gow Andrew and Harry Ischiropoulos, "Super-SOD: superoxide dismutase chimera fights off inflammation," Am J Physiol Lung Cell Mol Physiol, Vol. 284, Issue 6, L915-L916, June 2003 Low SOD fights inflammation Greiner Kathy, "Observational studies on effectiveness of super Glisodin," 2005. Greiner Benefits of Glisodin article is no longer active. Houghton Christine, "letter re GliSODin availablity in Australia," Cell Logic, December 5, 2006. [ General Principles of Superoxide dismutase in disease, Orgotein Therapy and SOD-mimetic Therapy, catalogued under 12 sections. Relevant article reviews ] Houghton article about GliSODin Australia is no longer available.
Kiefer Dale, "Superoxide Dismutase, Boosting the Body’s Primary Antioxidant Defense," LE Magazine June 2006. Kiefer article about SOD and aging is no longer active. Kinds of Antioxidants: Three first line intracellular antioxidant enzymes are Super Oxide Dismutase (SOD), Catalase (Cat) and Glutathione peroxidase (GPx). The SOD enzyme system exists in three different forms based on different minerals, zinc, copper and manganese, that aid in forming the three SOD enzymes. Li, et al., Y. (1995). "Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase.". Nat. Genet. 11: 376-381 Li mice study is no longer active. Myers Steve, "Basic Instinct: Immunity," Natural products marketplace, August 11, 2006. Myers article about natural immunity is no longer active. The presence of minerals, including zinc and copper, is also important to production of superoxide dismutase (SOD), an endogenous enzyme that provides various antioxidant protections to cells. SOD coated in a wheat gliadin layer (as GliSODin™, from P.L. Thomas [PLT]) has been found to stimulate production of nitric oxide and control production of superoxide anion by macrophages, helping to modulate immune function by controlling expression of cytokines and other antioxidant enzymes. Pansarasa O, Castagna L, Colombi B, Vecchiet J, Felzani G, Marzatico F. Age and sex differences in human skeletal muscle: role of reactive oxygen species. Free Radic Res. 2000 Sep;33(3):287-93. Sears Al, "After 4 Hours in the Sun I Didn't Burn at All!" Doctor's House Call, June 08, 2010. Sears Prevent sunburns without sunscreens Sear's Radiance formula:
Siddique Teepu, "Researchers discover genetic link between both types of ALS," May 07,2010. Siddique, and article Link SOD and ALS or Lou Gehrig's disease is no longer active. SOD, Indepth information. SOD Indepth info Superoxide dismutase, Bionity, [ references refer to those in this document ]:
Vouldoukis Ioannis, Marc Conti, Pascal Krauss, Caroline Kamaté, Samantha Blazquez, Maurel Tefit, Dominique Mazier, Alphonse Calenda, Bernard Dugas, "Supplementation with gliadin-combined plant superoxide dismutase extract promotes antioxidant defences and protects against oxidative stress," March 01, 2005, Volume 18 Issue 12, Pages 957 - 962. Vouldoukis article about validation of SOD is no longer active. "Abstract: It is concluded that supplementation with gliadin-combined standardized melon SOD extract (Glisodin®) promoted the cellular antioxidant status and protected against oxidative stress-induced cell death." Wikipedia, " Superoxides." wiki superoxides |