Supercharging the Immunity System
By Walter

[ Updated July 13, 2010; updated March 16, 2016.  Disclaimer The information presented here is for informative and educational purposes only and is not intended as curative or prescriptive advice.

Understanding how the body makes its own immune enhancing system

happyfambeachMost of us are familiar with vaccines and that immunizations help prevent influenza and diseases.  But that may be the extent of our knowledge about the immune system and how it really works. This article shares information about how our immune system can be supercharged with a new supplement called GliSODin.

But first, a brief background about why we need an immune system and then how an Superoxide Dismutase [ SOD ] helps to make the immune system work.

Our immune system is part of our body's need to get rid of wastes.Oxidants are waste products formed when oxygen is used to metabolize food and make energy. These oxidants are also referred to as free radicals because they are very unstable and circulate in the body looking to attach to body cells, in an effort to stabilize.  An excess of free radicals can interfere with normal body processes, such as disrupting our protection system, the immune system.  Alone or in combination with primary factors, free radicals are involved in the cause of hundreds of diseases.

To avoid free radical build up, babies are born with the antioxidant ability to fight and get rid of free radicals.  These early life antioxidants are referred to as Superoxide Dismutase or SOD.

Superoxide dismutase has been found in almost all organisms living in the presence of oxygen, including some anaerobic bacteria.  In humans, three forms of superoxide dismutase are present. SOD1 is located in the cytoplasm, SOD2 in the mitochondria and SOD3 is extracellular. The physiological importance of SODs is illustrated by the severe pathologies evident in mice genetically engineered to lack these enzymes. Mice lacking SOD2 die several days after birth, amidst massive oxidative stress. Mice lacking SOD1 develop a wide range of pathologies, including hepatocellular carcinoma, an acceleration of age-related muscle mass loss, an earlier incidence of cataracts and a reduced lifespan. Mice lacking SOD3 do not show any obvious defects and exhibit a normal lifespan. All three are essential for human well-being and staying alive!

SOD is made at birth but rapidly decreases with age. Excellent Background info | SOD and agingYour body starts pumping SOD into your system in the first few hours of baby life. It’s absolutely necessary for survival. Unfortunately, this capability to synthesize SOD dissipates early in life, so that as we grow older we have less and less ability to synthesize SOD.

The main antioxidants created by the body, SOD, is the first line of defense against the free radical substance called superoxide. In absence of the first defensive line of SOD, we also have a backup system of getting antioxidants from eating foods rich in SOD, like broccoli, cabbage, greens, ground flax seed, melons and fruits.  Unfortunately, foods provide such a weak second line of defense against free radicals that free radicals can over accumulate and disrupt [ stress ] our immune system. The immune system is particularly compromised by smoking, pollution, exposure to sunlight [ UV radiation ], infection, processed foods, sugars and aging; resulting in "oxidative stress." [ a condition where more oxygen wastes or free radicals accumulate than can be removed by antioxidants from the body, causing stress on cells to survive. ]

So, as children, teenagers and adults, we need SOD for survival and staying healthy.  Unfortunately the supplement SOD is immediately destroyed by stomach acids when ingested orally.  Commonly available SOD supplements are obviously ineffective and do not work. Excellent Background info

Scientists in France overcame this problem by wrapping SOD in a protective film or capsule wheat protein [ Gliadin ] that protects SOD from being broken down by stomach acids. Supplementing with this new supplement, GliSODin®, now allows your body to absorb SOD without destruction. Excellent Background info    Superoxide SOD research

GliSODin® is purported to stimulate the body to make its own internal antioxidants, including the major one --- SOD.  These are your own body's first line of defense against oxidants or  free radicals produced during body processes. SOD helps your body get rid of free radicals, suppresses inflammation and enhances immunity. SOD and aging
glisodinwheatmelon  Glisodin  is a cantaloupe melon extract rich in vegetal superoxide dismutase (SOD) covered by polymeric films of wheat matrix gliadin. Glisodin has been shown to be orally effective in several in vivo studies on animals as well as in clinical trials.  In these studies, glisodin has been shown to preserve the antioxidant activity of the SOD enzyme, resulting in an increase in organ and circulating SOD levels. This action has demonstrated therapeutic benefits by helping the body to handle and recover from stress. Glisodin organization info

GliSODin is an "enzyme of life" that is credited with being a natural body anti-oxidant that prolongs life, enhances immunity, prevents diseases and protects against sunburn.

 SOD Background:  

SOD, dubbed the “enzyme of life” on discovery in 1968, is the first antioxidant mobilized by the cell as defense against oxidative stress. The enzyme reacts with the superoxide ion and turns it into hydrogen peroxide (H2O2). This is then catabolized by catalase and glutathione peroxidase to produce molecular oxygen (O2) and water (H2O).  Monograph of research info

sod process

Figure: Role of antioxidant enzymes in the inactivation of the superoxide ion. Monograph of research info

These antioxidant [ SOD ] enzymes have a distinct advantage over the antioxidants consumed from the diet or nutritional supplements, like the vitamins A, C, and E, carotenoids, and thiols; since the SOD enzymes are biological catalysts, rapidly and repeatedly reducing reactive oxygen species without being consumed themselves. By reacting early in the process, the antioxidant enzymes can minimize the potentially-harmful oxidation of a range of biological molecules.   Monograph of research info

 glisod2Kinds of Antioxidants: Three first line intracellular antioxidant enzymes are Super Oxide Dismutase  [ SOD ], Catalase (Cat) and Glutathione peroxidase (GPx).  The SOD enzyme system exists in three different forms based on different cofactor minerals: zinc, copper  and manganese, that aid in forming the three SOD enzymes. SOD forms and cofactors

 Biochemistry:   Figure on the right above illustrates these concepts. A Primary Antioxidant SOD Enzyme recycles itself again and again, quenching many thousands of free radicals at their initial source. By contrast, Secondary Antioxidants such as those consumed in foods and supplements quench only ONE free radical for each antioxidant.

 Free Radicals and SOD 

SOD, a natural body enzyme and an antioxidant, has the power to intercept many seemingly-unrelated disease processes. It does this by neutralizing the many thousands of toxic free radicals, referred to as superoxides.   Because superoxide is toxic, nearly all organisms living in the presence of oxygen contain isoforms of the superoxide scavenging enzyme, superoxide dismutase, or SOD.  wiki superoxides  SOD is an extremely efficient enzyme; it catalyzes the neutralization of superoxide nearly as fast as the two can diffuse together spontaneously in solution. wiki superoxides By far the greatest source of superoxide generation in cells is the mitochondria. It is in the mitochondria that oxygen breaks down glucose to release ATP as energy for the body.  This process explains why SOD may help athletes to recuperate faster from exercise fatigue.

Oxygen utilization in ‘burning’ glucose to produce ATP is not 100% efficient and around 2-4% of oxygen used in the mitochondria ‘leaks’ out and is converted to the free radical Superoxide. SOD, and GliSODin in particular,  regulate [ neutralize ] superoxide at its mitrochondria source.  Doing the neutalizing of superoxide at its source saves other processes from doing it downstream in an inefficient manner that can result in free radicals piling up and inhibiting the metabolic processes and destroying healthy cells.  Glisodin brochure

Thus, thanks to SOD, the body can make its own system of antioxidants to get rid of free radicals.  Unfortunately, this capability to do so erodes early in life, so that as we grow older we have less and less ability to do so. The main antioxidant, SOD, is the first line defense against the free radical substance superoxide. Superoxide SOD research  Eating foods rich in SOD, like broccoli, cabbage, greens, melons and fruits, provides a much weaker second line of defense.

Internally produced antioxidants, ”including the enzymes superoxide dismutase (SOD) and catalase,” are the body's primary defense against free radical assault, offering up to thousands of times more protection against certain dangerous free radicals than dietary antioxidants.

Research done on mice and human volunteers has validated the effectiveness and safety of using GliSODin®:

Study 1 pilot trial: which involved a small group of people to determine potential for larger studies that confirm or reaffirm initial findings. This involved 15 people who redden easily or have hypersensitivity to the sun; for example, those who experience a sun rash from exposure. They were given 500 mg of GliSODin every day for two months. After three to eight weeks of normal sun exposure, all subjects reported higher tolerance and significantly diminished propensity to redden, flush or sun induced skin irritation, when compared to previous incidence of summer sun exposure. Germono Sun protection from inside

Study Pilot 2: on sun-protective capabilities of Glisodin was done in 2003 in France. 150 patients took GliSODin® every day for two months. Overall, 82% of people judged their skin was well prepared for sun exposure. This study was undertaken by 40 dermatologists in France and 150 individuals who were chosen based upon susceptibility to reddening, flushing and other reactions caused directly by the oxidative stress incurred by sun exposure. They too took 500 mg (2 x 250 mg doses) of GliSODin® daily for two months and kept sunbathing routines consistent. They were split into three groups: 75 patients with significant flushing or reddening almost immediately during exposure; 60 who experience sun reactions, and 15 patients who experience other reactions such as irritated skin. Results after four to eight weeks were as follows: 64 patients in the first group reported excellent tolerance; in group 2, 44 did not experience negative reactions, and in group 3, none reported the usual symptoms. A majority, 110 participants, judged that their skin was well prepared for sun exposure.
Germono Sun protection from inside

Study 3: Glisodin UV double blind controlled June 1, 2005:  used dietary supplement GliSODin® to demonstrate significant reduction in susceptibility to sunburn. Research study 2005
The third study was a randomized, double-blind trial of 50 subjects, 25 of whom took two 250 mg doses of GliSODin daily for four weeks. The goal of this study was to compare rates of reddening between the placebo and supplement takers, divided into three categories of phototypes. These are classified by amount of melanin pigment in the skin. In this study, there were phototypes II (fair skin, reddens easily, tans poorly), III (darker white skin that tans after exposure) and IV (light brown/olive skin that is more resistant.) Researchers controlled exposure by using an UV light to test photo-oxidative stress on the skin of the inner forearms, causing reddening and then measuring the change in the color of the redness (erythema). The redness was less pronounced and also decreased more quickly in the GliSODin group. The study confirms the efficacy of GliSODin in the prevention of the consequences of oxidative stress from exposure to the sun. Germono Sun protection from inside

Study 4: Glisodin and immune system HIV 2006:  GliSODin® was shown to restore the circulating antioxidant capacities, including Superoxide Dismustase (SOD); boosts T-cells. The effects of an orally effective SOD (Glisodin) on AIDS West African patients in a randomized double-blinded clinical study,” was conducted by French and American Researchers with HIV patients in the Ivory Coast. Aids conf 200  This information suggests that GliSODin® may be helpful in preventing autoimmune diseases.  Low SOD fights inflammation

Study 5: Prevent Macular Degeneration in eyes November 14, 2006:  Results of a new study, using the exclusive dietary supplement ingredient, GliSODin®, demonstrated significant protection against induced oxidative stress and retinal tissues in an animal model. In this study, GliSODin® supplementation limited retinal oxidative stress [ damage ] and improved plasma antioxidant status.  Protect eyes

Study 6: Prevent CVD:  Additional studies link GliSODin® to prevention of cardiovascular diseases. For example: "A three-year study with GliSODin® supplementation showed significant benefits for cardiovascular health. GliSODin® promoted arterial health and function compared to the control group as measured by the thickness of the participants' carotid arteries. Further, GliSODin® significantly improved the antioxidant status and provided a reduction in measures of lipid oxidation. The researchers called the results "remarkable." Glisodin, gliadin and CVDPL Thomas

Possibly prevent Lou Gehrig's disease:  Researchers have discovered genetic link between SOD and ALS. Researchers from Northwestern University Feinberg School of Medicine have discovered a link between sporadic and familial forms of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease also known as Lou Gehrig's disease. "This is a game changer because it establishes a connection in the development of sporadic ALS with a known cause of familial ALS," said senior author Teepu Siddique, M.D., the Les Turner ALS Foundation/Herbert C. Wenske Professor of the Davee Department of Neurology and Clinical Neurosciences at Feinberg and a neurologist at Northwestern Memorial Hospital.

"Our finding [ May, 2010 ] opens up a new field of investigation for rational therapy for all of ALS," Siddique added. "This is the holy grail of researchers in this field."  Link SOD and ALS or Lou Gehrig's disease

These and other studies Excellent Background info | Research timeline confirm that GliSODin® works. New research opens the door for further discoveries about how SOD and its related enzymes help promote good health. GliSODin Australia

The new research about GliSODin® indicates that those using Glisodin get 800 percent more sun protection . . . completely naturally.

More Observational Studies on the Effectiveness of Super Glisodin  
By ©Kathy Grenier, 2005 Greiner Benefits of Glisodin

Joint Health/Anti-Inflammation: Immediate relief to joints and inflammation, less cracking and creaking, more mobility, and less pain was observed in days.

Energy: Noticed more energy immediately, not a huge bump but a nice sustained energy from within, very pleasant.

Eye Health: After using Super Glisodin about 1-2 months, the white part of the eye is getting whiter and healthier looking, eyes look brighter.

Allergies: Observed that body is able to deal with allergens better, even amidst the worst allergy season (weed growth and population is through the roof this year due to lots of rain). Does not completely eliminate the allergy condition, but is helping the body to cope better and to recover faster.

Muscle Support: Noticed that whenever physical work or exercise is performed, muscles develop quicker and more solid, and with less aches and pain.

Hair Color & Growth: After about 2 months of use, noticed less hair falling out, natural hair color is maintained (less white hair from stress), quicker new hair growth, and hair is shiner and smoother.

Immune Health: Observed extremely rapid recovery from common colds and flu conditions when person is taking Super Glisodin for first time. When using Super Glisodin on a regular basis, immune system stays healthy and strong, and able to avoid most colds. Seems to help alleviate excess stress on the immune system.

Detox/Colon Health: Observed a mild detoxifying effect, especially in the first several weeks. Elimination smoother, more regular, and may have more bulk. Digestion is easier and better. The cleansing effect, the intestines and colon could be helped further by using Ashi-Flora along with Super Glisodin.

Neurological Support: Noticed that Super Glisodin is so supportive to the brain that we had to cut back our dosage of Brain Lightning. Clarity of thoughts was enhanced, able to stay positive when dealing with problems, experienced overall sensation of relief to “brain stress”, had better focus. Super Glisodin makes a great companion product for Brain Lightning.

ADD/ADHD: Observed dramatic benefits to children (age 10-11), they were able to think more clearly, focus on details and “mundane” tasks, exhibited more self-motivation and initiative, their energy levels were more even through-out the day, and general improvement in physical well-being and brain function.

Skin Health: A surprise bonus – noticed that skin tissue is smoother, healthier, and more radiant, and only after 2-3 months of using Super Glisodin.

Personal Note: It is my [ Greiner ] feeling that Super Glisodin is an important foundation for any health program for all ages. It is my opinion that Super Glisodin is a necessary basis on which to build any herbal therapy, anti-aging therapy, developmental programs, or personal health programs. Super Glisodin is incredibly safe with no known side effects. As long as the ideal dosage is utilized for that individual’s needs, positive benefits can be realized very quickly.

Disclaimer:  These statements have not been approved by the FDA and these products are not intended to diagnose, cure, or treat any disease. These are personal observations and opinions, these statements are not intended to be conclusive scientific data. More research and study into these arenas and other health issues should be conducted and would be encouraged.

Greiner Kathy, Nutraceutical Formulator, Product Developer, Researcher.   Greiner Benefits of Glisodin

 Pharmacokinetic Studies and Dosage Considerations 

Pharmacokinetic studies to determine the optimal dosage showed that one 250mg capsule begins to up-regulate endogenous synthesis of SOD around 3 hours after consumption. A steep increase over the next 3 hours reaches a maximum threshold which is maintained at this level over approximately 6 hours, after which the enzyme levels fall away. It is apparent that after ingestion of one GliSODin capsule, SOD levels are elevated after 3 hours and remain so for a further 9 hours  [3 Vouldoukis ].

Assumingly, dosing of 2 capsules daily approximately 12 hours apart should provide almost continuous induction of SOD. Furthermore, continuous dosing of 2 capsules daily as described above gradually increases the maximal threshold to a peak reached at around 28 days.

A significant benefit of GliSODin over any of the SOD-mimetic drugs lies in its ability to substantially upregulate all 3 Antioxidant Enzymes, Superoxide Dismutase, Glutathione peroxidase and Catalase.  [4 Vouldoukis]  In this way, the function of GliSODin more closely approximates that of more youthful human Antioxidant Enzyme activity.

Dosage:  There is some confusion about the best Glisodin dosage; suggestions ranging between 100 to 300IU per day; such as base dosage is equivalent to 100 IU of SOD per day. SOD Indepth info  Vouldoukis pointed out earlier that a dosage of 250 IU per day maintained a high level of SOD for 12 hours.  Ingesting a 250IU capsule every 12 hours would allow the immune system to activate its own catalytic action.

GliSODin® is available in high potency as Super GliSODin, offering 250 mg in each vegetable capsule, 60 capsules per bottle; and as GliSODin, offering 100 mg in each vegetable capsule, 90 capsules per bottle.  dosage availability This dosage may vary with merchants and capsule size. The suggested dosage per day is 250 IU of GliSODin®. Swanson Health Products online sells Glisodin Ultra for $18.99 [ + shipping ][ 60 caps (size = 00) each at 300 mg ].

 Safety:   GliSODin® is a completely vegetarian product that is well tolerated and is safe to consume.  GliSODin® does contain wheat ingredient and a source of gluten.   GliSODin® is not recommended for anyone with wheat or gluten sensitivity.  Glisodin safety    You should have your health therapist monitor you while taking supplements. 

 Test:   Although serum blood tests EconoLabs Private MD Labs are available, costing about $90, more information was not found.

 Conclusion:  GliSODin® enhances the body's ability to tolerate sunlight by providing natural body antioxidants.  But its importance to overall health has been overlooked by the medical and scientific communities.  It provides a bolster of SOD the the human body so desperately needs. The SOD enzyme system, Super Oxide Dismutase (SOD), Catalase (Cat) and Glutathione peroxidase (GPx), are essential for human well-being and staying alive!

SOD is King of the Hill

Antioxidant

Protection Level

Primary Antioxidants

 

SOD

Highest

Catalase

Exceptional

Glutathione Peroxidase (Gpx)

Exceptional

Secondary Antioxidants

 

Glutathione, CoQ10

Very Strong

Carotenoids, Vitamin E

Strong

Flavinoids, Vitamins A, C

Strong

Minerals, Proteins

Moderate

Source: Sears, Al, Doctor's House Call, July 16, 2010.

GliSODin is reported to be able to supercharge the body to make it's own antioxidants; referred to in general as SOD.  These natural body SODs can be used many times catalytically to neutralize free radicals without the need to be replenished as food source antioxidants do.

SOD and especially the supplement GliSODin® need to be given equal priority with amino acids, vitamin D, vitamin C, magnesium, amino acids, minerals and other nutrients and related co-factors in maintaining high immunity and preventing diseases. SOD and aging  Collectively these essential nutrients make up the future medical arsenal.   GliSODin Australia

References

[[1] Ceriello New Insights on Oxidative Stress and Diabetic Complications May lead to a ‘causal’ antioxidant therapy. Diabetes Care 26:1589-1596, 2003

[2] Catassi et al A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease American Journal Clinical Nutrition January, 2007. Vol. 85, No. 1, 160-166

[3] Vouldoukis, M. Conti, P. Krauss, C. Kamate, S. Blazquez, M. Tefit, D. Mazier, A. Calenda, B. Dugas. “Supplementation with gliadin-combined plant superoxide dismutase extracts promotes antioxidant defenses and protects against oxidative stress,” Phytotherapy Res, Mar 1;18(12) (2004) 957-962 PMID: 15742357 Glisodin promotes antioxidation

[4] Vouldoukis, D. Lacan, C. Kamate, P. Coste, A. Caldnda, D. Mazier, M. Conti, B. Dugas. “Antioxidant and anti-inflammatory properties of a Cucumis melon extract rich in superoxide dismutase activity,” J. Ethnopharmacology. 94 (2004) 67-75 PMID: 15261965

[5] Muth et al. Influence of an Orally Effective SOD on Hyperbaric Oxygen-related cell damage. Free Radical Research Volume 38, Number 9 / September, 2004. 927-932

[6] Bader et al. Influence of Vitamin C and E supplementation on Oxidative Stress Induced by Hyperbaric Oxygen in Healthy Men. Ann. Nutr. Metab. 2006;50:173-176

[7] Cloarec M et al. GliSODin, a vegetal SOD with Gliadin as preventive agent vs atherosclerosis, as confirmed with Ultrasound-B imaging. Glisodin, gliadin and CVD "Supplementation with GliSODin®, a vegetal SOD associated with gliadin, was effective in controlling the thickness of the carotid artery intima and media layers as measured by ultrasonography-B. We could demonstrate the preventive efficacy of GliSODin at a preclinical stage in subjects with risk factors of cardiovascular disease."

[8] Crouse JR et al. The Meteor Trial JAMA 2007;297:1344-1353/p>

[9] Brownlee, M. Banting Lecture 2004. The Pathobiology of Diabetic Complications: A Unifying Mechanism; DIABETES, VOL. 54, JUNE 2005; 1615-1625

[10] Naito T. et al. Reduction of diabetes-induced renal oxidative stress by a cantaloupe melon extract/gliadin biopolymers Oxykine in mice BioFactors Vol 23, Number 2 / 2005

[11] F. Marzatico, O. Pansarasa, L. Bertorelli, L. Somenzini, G. Della Valle. “Blood free radical antioxidant enzymes and lipid peroxides following long-distance and lactacidemic performances in highly-trained aerobic and sprint athletes,” Journal of Sports Medicine and Physical Fitness. (1997) Dec. 37(4) 235-9 PMID: 9509820

Antioxidants, free radical and oxidative stress: Antioxidants what are these?

Bradley, Kyle, "Building bombproof immunity," Virgo Publishing, 2010, September 24, 2007.  Bradley Building immunity

Camara Anne-Laure, Dir Dev & Auality Assurance., Isocell Nutra SAS, Paris, France  "Develpment of GliSODin"  Camara: contact Cell-Logic

Chenal Henri, et la., "Restored antioxidant circulating capacities in AIDS with Glisodin ...," Research letter to France. 2004.  Glisodin affect on AIDS

Cloarec M., et la., "GliSODin, a vegetal sod with gliadin, as preventative agent vs. atherosclerosis, as confirmed with carotid ultrasound-B imaging," Eur Ann Allergy Clin Immunol., 2007 Feb;39(2):45-50. Glisodin preventing CVD

Germano Carl, "Sun Protection from the Inside!" Millennium Biotechnologies Group Inc.  Germono Sun protection from inside 

Glisodin, "About Glisodin." Glisodin organization.  About Glisodin  | Research about Glisodin

Glinsodin,"Backgrounder, "Glinsidin Media Center. Excellent Background info

Free Radicals, Antioxidants and SOD

"Oxygen is necessary to sustain life, yet the very process of oxygen metabolism in the cells creates destructive elements called free radicals. Free radicals, or oxidants, are chemically unbalanced, carrying free electrons that can damage molecules in our cells while trying to achieve balance – potentially damaging the cell itself.  This free radical damage, also called oxidative stress, is widely accepted as the free radical theory of aging.

  Fortunately, the body has its own free radical defense system.  Virtually every cell produces antioxidant enzymes called Superoxide Dismutase (SOD), catalase and glutathione peroxidase. 

 These enzymes protect the cells during oxygen metabolism, safely breaking down harmful free radicals to balanced elements like H20.

  Dietary antioxidants, such as the vitamins A, C, E, play a secondary, supporting role.  They act as free radical scavengers by “donating” an electron to provide chemical balance.  These antioxidants become quickly saturated – only once can they donate an electron."

Ideally, the balance between the production of free radicals and our antioxidant defenses is maintained. 

 

However, our antioxidant defense system can become overwhelmed.  Studies indicate the levels of SOD, catalase and Gpx decrease with age.  Also, certain conditions are related to the increased production of unstable oxygen derivatives, including physical stress, health challenges and exposure to environmental toxins such as smoking and pollution. 

When the antioxidant systems of defense are overloaded, oxidative stress (free radicals in excess) may occur."

Glisodin organization, "About Glisodin."  Glisodin organization info | Monograph of research info

GliSODin  Glisodin brochure

GliSODin® June 8, 2010.  GliSODin®

Glisodin is a nutritional supplement based on two constituents:

GliSODin® may provide significant protection, follow-up research study against UV radiation-induced skin changes  Protection against sunlight

"GliSODin supplementation resulted in an increase in the minimum exposure to UV rays necessary to produce skin burn. In particular, phototypes II required eight times greater exposure than that of the placebo."

Glisodin, Research timetable. Timetable research

Glisodin: Selected References

Glisodin, "Technical Monograph," [ Literature Review of a cantaloupe melon concentrate naturally rich in Superoxide Dismutase/ wheat gliadin biopolymer, (GliSODin®) and its beneficial health aspects ]  Tech monograph

Gow Andrew and Harry Ischiropoulos, "Super-SOD: superoxide dismutase chimera fights off inflammation," Am J Physiol Lung Cell Mol Physiol, Vol. 284, Issue 6, L915-L916, June 2003  Low SOD fights inflammation

Greiner Kathy, "Observational studies on effectiveness of super Glisodin," 2005.  Greiner Benefits of Glisodin

Houghton Christine, "letter re GliSODin  availablity in Australia," Cell Logic, December 5, 2006. [ General Principles of Superoxide dismutase in disease, Orgotein Therapy and SOD-mimetic Therapy, catalogued under 12 sections. Relevant article reviews ]  GliSODin Australia

"What much of the research into Oxidative Stress reveals is that antioxidants are not all alike; those antioxidants like vitamin E and beta-carotene which reside in the membrane target different Reactive Oxygen Species (ROS) from those in the cytoplasm or in the mitochondria. Clearly, we are not dealing with a ‘one size fits all’ situation. A clear understanding of the different ROS and the antioxidants most targeted to quench or scavenge each one aids in more effective clinical intervention. Vitamin E therapy has proved most disappointing in addressing endothelial dysfunction; this is most likely due to the fact that Vitamin E acts too far downstream to be effective. By contrast, those agents which quench Superoxide early in the free radical generation process (such as GliSODin) have demonstrated significant clinical efficacy.

Superoxide dismutase therapy using GliSODin opens up a whole world of new clinical possibilities, providing Clinicians with a targeted tool which gets much closer to addressing disease at a more fundamental source."

International Aids Conference, "GliSODin Oxidative Stress Study Presented at the 2006 International AIDS Conference," Toronto, Canada, August 15, 2006. Aids conf 2006   GliSODin study on oxidative stress in immune compromised humans.

Kiefer Dale, "Superoxide Dismutase, Boosting the Body’s Primary Antioxidant Defense," LE Magazine June 2006.  SOD and aging

Kinds of Antioxidants: Three first line intracellular antioxidant enzymes are Super Oxide Dismutase (SOD), Catalase (Cat) and Glutathione peroxidase (GPx).  The SOD enzyme system exists in three different forms based on different minerals, zinc, copper and manganese, that aid in forming the three SOD enzymes.

Li, et al., Y. (1995). "Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase.". Nat. Genet. 11: 376-381 Li mice study

MAC-MARY S., J.M.SAINTHILLIER, C. COURDEROTMASUYER, P. CREIDI, P. HUMBERT, "Could a photobiological test be a suitable method to assess the antioxidant effect of a nutritional supplement (Glisodin®)?" Eur J Derm vol 17 n April 3, 2007.  Glisodin Test inconclusive

Myers Steve, "Basic Instinct: Immunity," Natural products marketplace, August 11, 2006.  Natural immunity

The presence of minerals, including zinc and copper, is also important to production of superoxide dismutase (SOD), an endogenous enzyme that provides various antioxidant protections to cells. SOD coated in a wheat gliadin layer (as GliSODin™, from P.L. Thomas [PLT]) has been found to stimulate production of nitric oxide and control production of superoxide anion by macrophages, helping to modulate immune function by controlling expression of cytokines and other antioxidant enzymes. Vouldoukis SOD protection

 “Antioxidants, particularly those produced by our bodies—such as SOD—are vitally important to immunity,” said Eric Anderson, brand manager for PLT. He cited research showing GliSODin as effective in immune stimulation in HIV patients is based on protection of T cells. “Apoptosis of T cells is characteristic of HIV and AIDS, and free radicals contribute to this event,” he said, adding consumers not immune compromised can also benefit from SOD antioxidant protection of T cells and other immune cells.

Also common in HIV patients, deficiency of the mineral selenium wreaks havoc on immune function. University of Miami scientists studying the effects of selenium deficiency on HIV associated selenium levels to T cell function and apoptosis, noting selenium may enhance resistance to infection by modulating IL production and Th1 and Th2 response. Miquez infection


Selenium deficiency may allow invading viruses to mutate and remain for a longer period in the host, according to research from the University of North Carolina, Chapel Hill.  They found selenium-deficient animals exposed to human influenza virus (flu) experienced more severe and longer lasting flu, including lung inflammation, than the non-deficient mice.

Scientists have also logged success with selenium supplementation on immune response, especially combined with vitamin E, which results in interactive effects as oxygen radical scavengers, thereby promoting human lymphocyte response to antigens.Nelson selenium    Additional research on this combination therapy showed it enhances the body’s response to bacterial Lee antioxidants and parasitic infections.  Berg selenium protection

Oxidative stress The oxidative stress produced by these oxidation chemicals can damage cells and tissues, causing cell death.

Pansarasa O, Castagna L, Colombi B, Vecchiet J, Felzani G, Marzatico F. Age and sex differences in human skeletal muscle: role of reactive oxygen species. Free Radic Res. 2000 Sep;33(3):287-93.

Sears Al, "After 4 Hours in the Sun I Didn't Burn at All!" Doctor's House Call, June 08, 2010.  Sears Prevent sunburns without sunscreens

Sear's Radiance formula:

Nutrient

Source

Benefit

Gamma-linolenic acid (GLA)

Vegetable oils

Promotes normal inflammatory response, immune booster, cellular building block*

Sea Buckthorn oil

Berries of a plant native to Europe and Asia

Rich in antioxidants, anti-aging power, promotes skin cell regeneration*

Mixed tocopherols (Vit. E)

Leafy greens, seeds and nuts

Promotes normal inflammatory response, antioxidant, DNA repair, immune booster, protects cell membranes*

High omega flax seed oil

Flowering plant native to Canada

Antioxidant, accelerates healing*

Hyaluronic acid

Root vegetables

Basic building block of tissue throughout the body, anti-aging, cell repair and healing, reduces wrinkles, keeps skin firm and elastic*

Raspberry seed oil

Raspberries

Antioxidant, healing agent*

GliSODin®

Patented “antioxidant catalyst” from France

Ramps up your body’s production of a super powerful antioxidant enzyme; promotes normal inflammatory response, immune booster, detoxifies cell tissue*

Siddique Teepu, "Researchers discover genetic link between both types of ALS,"  May 07,2010.  Link SOD and ALS or Lou Gehrig's disease

SOD, Indepth information. SOD Indepth info

Superoxide dismutase, Bionity,  SOD forms and cofactors [ references refer to those in this document ]

"In humans, three forms of superoxide dismutase are present. SOD1 is located in the cytoplasm, SOD2 in the mitochondria and SOD3 is extracellular. The first is a dimer (consists of two units), while the others are tetramers (four subunits). SOD1 and SOD3 contain copper and zinc, while SOD2 has manganese in its reactive centre. The genes are located on chromosomes 21, 6 and 4, respectively (21q22.1, 6q25.3 and 4p15.3-p15.1).

Physiology

Superoxide is one of the main reactive oxygen species in the cell and as such, SOD serves a key antioxidant role. The physiological importance of SODs is illustrated by the severe pathologies evident in mice genetically engineered to lack these enzymes. Mice lacking SOD2 die several days after birth, amidst massive oxidative stress[2]. Mice lacking SOD1 develop a wide range of pathologies, including hepatocellular carcinoma[3], an acceleration of age-related muscle mass loss[4], an earlier incidence of cataracts and a reduced lifespan. Mice lacking SOD3 do not show any obvious defects and exhibit a normal lifespan[5].

Role in disease

Mutations in the first SOD enzyme (SOD1) have been linked to familial amyotrophic lateral sclerosis (ALS, a form of motor neuron disease). The other two types have not been linked to any human diseases, however, in mice inactivation of SOD2 causes perinatal lethality[2] and inactivation of SOD1 causes hepatocellular carcinoma[3]. Mutations in SOD1 can cause familial ALS, by a mechanism that is presently not understood, but not due to loss of enzymatic activity. Over expression of SOD1 has been linked to Down's syndrome[6]. The veterinary anti-inflammatory drug "Orgotein" is purified bovine liver superoxide dismutase."

Superoxide dismutase research  Superoxide SOD research

Swanson Health Store:  300 mgs 60 caps $19.00  [ one month supply ] Swanson best buy

Tkachenko E., Uspensky U., Avaluev E., Oreshko L.,Research of in-patient efficaciousness of the biologically active addition to food Glisodin in therapeutic practice,” St. Petersburg State Medical Academy, St. Petersburg, Russia. (Oct. 5, 2005)

Vouldoukis Ioannis, Marc Conti, Pascal Krauss, Caroline Kamaté, Samantha Blazquez, Maurel Tefit, Dominique Mazier, Alphonse Calenda, Bernard Dugas, "Supplementation with gliadin-combined plant superoxide dismutase extract promotes antioxidant defences and protects against oxidative stress," March 01, 2005, Volume 18 Issue 12, Pages 957 - 962.   Vouldoukis: validation SOD  "Abstract: It is concluded that supplementation with gliadin-combined standardized melon SOD extract (Glisodin®) promoted the cellular antioxidant status and protected against oxidative stress-induced cell death."

Wikipedia, " Superoxides." wiki superoxides

Additional SOD RESEARCH References:  More SOD research

1: Shimizu K, Rajapakse N, Horiguchi T, Payne RM, Busija DW. 
Neuroprotection against hypoxia-ischemia in neonatal rat brain by novel superoxide dismutase mimetics.
Neurosci Lett. 2003 Jul 31;346(1-2):41-4. 
PMID: 12850543 

2: Shimmura S, Igarashi R, Yaguchi H, Ohashi Y, Shimazaki J, Tsubota K. 
Lecithin-bound superoxide dismutase in the treatment of noninfectious corneal ulcers.
Am J Ophthalmol. 2003 May;135(5):613-9. 
PMID: 12719067 

3: Jobe AH. 
An unanticipated benefit of the treatment of preterm infants with CuZn superoxide dismutase.
Pediatrics. 2003 Mar;111(3):680. 
PMID: 12612258 

4: Davis JM, Parad RB, Michele T, Allred E, Price A, Rosenfeld W; North American Recombinant Human CuZnSOD Study Group. 
Pulmonary outcome at 1 year corrected age in premature infants treated at birth with recombinant human CuZn superoxide dismutase.
Pediatrics. 2003 Mar;111(3):469-76. 
PMID: 12612223 

5: Yunoki M, Kawauchi M, Ukita N, Sugiura T, Ohmoto T. 
Effects of lecithinized superoxide dismutase on neuronal cell loss in CA3 hippocampus after traumatic brain injury in rats.
Surg Neurol. 2003 Mar;59(3):156-60; discussion 160-1. 
PMID: 12681536 

6: Serkedjieva J, Roeva I, Angelova M, Dolashka P, Voelter WG. 
Combined protective effect of a fungal Cu/Zn-containing superoxide dismutase and rimantadine hydrochloride in experimental murine influenza a virus infection.
Acta Virol. 2003;47(1):53-6. 
PMID: 12828346 

7: Salvemini D, Cuzzocrea S. 
Therapeutic potential of superoxide dismutase mimetics as therapeutic agents in critical care medicine.
Crit Care Med. 2003 Jan;31(1 Suppl):S29-38. Review. 
PMID: 12544974 

8: Paramonov BA, Churilova IV, Zinov'ev EV, Chebotarev VY. 
Erysod, erythrocyte superoxide dismutase preparation: effects on LPO processes and morphological changes in the viscera of rats with burns under conditions of delayed antishock infusion therapy.
Bull Exp Biol Med. 2002 Dec;134(6):578-82. 
PMID: 12660843 

9: Churilova IV, Zinov'ev EV, Paramonov BA, Drozdova YI, Sidel'nikov VO, Chebotarev VY. 
Effect of Erysod (erythrocyte superoxide dismutase) on blood concentration of reactive oxygen species in patients with severe burns and burn shock.
Bull Exp Biol Med. 2002 Nov;134(5):454-6. 
PMID: 12802450 

10: Vorauer-Uhl K, Furnschlief E, Wagner A, Ferko B, Katinger H. 
Reepithelialization of experimental scalds effected by topically applied superoxide dismutase: controlled animal studies.
Wound Repair Regen. 2002 Nov-Dec;10(6):366-71. 
PMID: 12453140 

11: Luisa Corvo M, Jorge JC, van't Hof R, Cruz ME, Crommelin DJ, Storm G. 
Superoxide dismutase entrapped in long-circulating liposomes: formulation design and therapeutic activity in rat adjuvant arthritis.
Biochim Biophys Acta. 2002 Aug 19;1564(1):227-36. 
PMID: 12101017 

12: Zhang Y, Wang JZ, Wu YJ, Li WG. 
Anti-inflammatory effect of recombinant human superoxide dismutase in rats and mice and its mechanism.
Acta Pharmacol Sin. 2002 May;23(5):439-44. 
PMID: 11978194 

13: Giardino R, Giavaresi G, Fini M, Torricelli P, Guzzardella GA. 
The role of different chemical modifications of superoxide dismutase in preventing a prolonged muscular ischemia/ reperfusion injury.
Artif Cells Blood Substit Immobil Biotechnol. 2002 May;30(3):189-98. 
PMID: 12066874 

14: Bone HG, Sakurai H, Schenarts PJ, Traber LD, Traber DL. 
Effects of manganese superoxide dismutase, when given after inhalation injury has been established.
Crit Care Med. 2002 Apr;30(4):856-60. 
PMID: 11940759 

15: Davis JM. 
Role of oxidant injury in the pathogenesis of neonatal lung disease.
Acta Paediatr Suppl. 2002;91(437):23-5. Review. 
PMID: 12200893 

16: Ivanova E, Angelova M, Slokoska L, Pashova S, Toshkova R, Dolashka-Angelova P, Dimitrova P, Voelter W. 
Effect of Cu/Zn-superoxide dismutase from the fungal strain Humicola lutea 103 on antioxidant defense of Graffi tumor-bearing hamsters.
Z Naturforsch [C]. 2002 Jan-Feb;57(1-2):197-204. 
PMID: 11926535 

17: Nishikawa M, Nagatomi H, Nishijima M, Ohira G, Chang BJ, Sato E, Inoue M. 
Targeting superoxide dismutase to renal proximal tubule cells inhibits nephrotoxicity of cisplatin and increases the survival of cancer-bearing mice.
Cancer Lett. 2001 Oct 10;171(2):133-8. 
PMID: 11520596 

18: Steinhorn RH, Albert G, Swartz DD, Russell JA, Levine CR, Davis JM. 
Recombinant human superoxide dismutase enhances the effect of inhaled nitric oxide in persistent pulmonary hypertension.
Am J Respir Crit Care Med. 2001 Sep 1;164(5):834-9. 
PMID: 11549542 

19: Riedl CR, Plas E, Vorauer K, Vcelar B, Wagner A, Pfluger H. 
Pilot study on liposomal recombinant human superoxide dismutase for the treatment of Peyronie's disease.
Eur Urol. 2001 Sep;40(3):343-8; discussion 348-9. Review. 
PMID: 11684853 

20: Yabe Y, Kobayashi N, Nishihashi T, Takahashi R, Nishikawa M, Takakura Y, Hashida M. 
Prevention of neutrophil-mediated hepatic ischemia/reperfusion injury by superoxide dismutase and catalase derivatives.
J Pharmacol Exp Ther. 2001 Sep;298(3):894-9. 
PMID: 11504782 

21: Epperly MW, Kagan VE, Sikora CA, Gretton JE, Defilippi SJ, Bar-Sagi D, Greenberger JS. 
Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation.
Int J Cancer. 2001 Aug 20;96(4):221-31. 
PMID: 11474496 

22: Hangaishi M, Nakajima H, Taguchi J, Igarashi R, Hoshino J, Kurokawa K, Kimura S, Nagai R, Ohno M. 
Lecithinized Cu, Zn-superoxide dismutase limits the infarct size following ischemia-reperfusion injury in rat hearts in vivo.
Biochem Biophys Res Commun. 2001 Aug 3;285(5):1220-5. 
PMID: 11478786 

23: Nakamura T, Ogawa Y. 
Prophylactic effects of recombinant human superoxide dismutase in neonatal lung injury induced by the intratracheal instillation of endotoxin in piglets.
Biol Neonate. 2001 Aug;80(2):163-8. 
PMID: 11509818 

24: Vorauer-Uhl K, Furnschlief E, Wagner A, Ferko B, Katinger H. 
Topically applied liposome encapsulated superoxide dismutase reduces postburn wound size and edema formation.
Eur J Pharm Sci. 2001 Aug;14(1):63-7. 
PMID: 11457651 

25: Kanamasa K, Ishida N, Ishikawa K. 
Protective effect of PEG-SOD against early coronary reperfusion injury assessed in reperfused and non-reperfused ischaemic areas of the same heart.
Acta Cardiol. 2001 Jun;56(3):181-6. 
PMID: 11471931 

26: Zanetti M, Sato J, Katusic ZS, O'Brien T. 
Gene transfer of superoxide dismutase isoforms reverses endothelial dysfunction in diabetic rabbit aorta.
Am J Physiol Heart Circ Physiol. 2001 Jun;280(6):H2516-23. 
PMID: 11356606 

27: de Bono S. 
SOD mimic minimizes pain.
Trends Biochem Sci. 2001 May;26(5):283. 
PMID: 11343917 

28: Zhong Z, Connor HD, Yin M, Wheeler MD, Mason RP, Thurman RG. 
Viral delivery of superoxide dismutase gene reduces cyclosporine A-induced nephrotoxicity.
Kidney Int. 2001 Apr;59(4):1397-404. 
PMID: 11260401 

29: Muzykantov VR. 
Targeting of superoxide dismutase and catalase to vascular endothelium.
J Control Release. 2001 Mar 12;71(1):1-21. Review. 
PMID: 11245904 

30: Nishikawa M, Nagatomi H, Chang BJ, Sato E, Inoue M. 
Targeting superoxide dismutase to renal proximal tubule cells inhibits mitochondrial injury and renal dysfunction inuduced by cisplatin.
Arch Biochem Biophys. 2001 Mar 1;387(1):78-84. 
PMID: 11368186 

31: Baumgardner KR, Sulfaro MA. 
The anti-inflammatory effects of human recombinant copper-zinc superoxide dismutase on pulp inflammation.
J Endod. 2001 Mar;27(3):190-5. 
PMID: 11487150 

32: Muzykantov VR. 
Delivery of antioxidant enzyme proteins to the lung.
Antioxid Redox Signal. 2001 Feb;3(1):39-62. Review. 
PMID: 11291598 

33: Petelin M, Pavlica Z, Ivanusa T, Sentjurc M, Skaleric U. 
Local delivery of liposome-encapsulated superoxide dismutase and catalase suppress periodontal inflammation in beagles.
J Clin Periodontol. 2000 Dec;27(12):918-25. 
PMID: 11140559 

34: Udipi K, Ornberg RL, Thurmond KB 2nd, Settle SL, Forster D, Riley D. 
Modification of inflammatory response to implanted biomedical materials in vivo by surface bound superoxide dismutase mimics.
J Biomed Mater Res. 2000 Sep 15;51(4):549-60. 
PMID: 10880102 

35: Nagler RM, Reznick AZ, Slavin S, Nagler A. 
Partial protection of rat parotid glands from irradiation-induced hyposalivation by manganese superoxide dismutase.
Arch Oral Biol. 2000 Sep;45(9):741-7. 
PMID: 10869487 

36: Dimitrova PA, Toshkova RA, Ivanova EH, Stefanova ZH, Angelova MB, Dolashka PA, Voelter W. 
Superoxide production by phagocytes in myeloid Graffi tumor-bearing hamsters.
Z Naturforsch [C]. 2000 Sep-Oct;55(9-10):799-805. 
PMID: 11098834 

37: Ratcheva I, Stefanova Z, Vesselinova A, Nikolova S, Kujumdjieva A, Neychev H. 
Treatment of adjuvant arthritis in mice with yeast superoxide dismutase.
Pharmazie. 2000 Jul;55(7):533-7. 
PMID: 10944784 

38: Kojima K, Matsui K, Nagase M. 
Protection of alpha(3) integrin-mediated podocyte shape by superoxide dismutase in the puromycin aminonucleoside nephrosis rat.
Am J Kidney Dis. 2000 Jun;35(6):1175-85. 
PMID: 10845833 

39: Vemulapalli R, He Y, Cravero S, Sriranganathan N, Boyle SM, Schurig GG. 
Overexpression of protective antigen as a novel approach to enhance vaccine efficacy of Brucella abortus strain RB51.
Infect Immun. 2000 Jun;68(6):3286-9. 
PMID: 10816475 

40: Davis JM, Richter SE, Biswas S, Rosenfeld WN, Parton L, Gewolb IH, Parad R, Carlo W, Couser RJ, Baumgart S, Atluru V, Salerno L, Kassem N. 
Long-term follow-up of premature infants treated with prophylactic, intratracheal recombinant human CuZn superoxide dismutase.
J Perinatol. 2000 Jun;20(4):213-6. 
PMID: 10879331 

41: Garcia-Gonzalez A, Morales-Hernandez RC, Porta-Gandara MA, Rubio-Cerda E, Ochoa JL. 
Superoxide dismutase and Naproxen in the very late phase of carrageenan induced edema in rats.
Rev Invest Clin. 2000 Mar-Apr;52(2):156-60. 
PMID: 10846439 

42: Swart PJ, Hirano T, Kuipers ME, Ito Y, Smit C, Hashida M, Nishikawa M, Beljaars L, Meijer DK, Poelstra K. 
Targeting of superoxide dismutase to the liver results in anti-inflammatory effects in rats with fibrotic livers.
J Hepatol. 1999 Dec;31(6):1034-43. 
PMID: 10604577 

43: Rios L, Cluzel J, Vennat JC, Menerath JM, Doly M. 
Comparison of intraocular treatment of DMTU and SOD following retinal ischemia in rats.
J Ocul Pharmacol Ther. 1999 Dec;15(6):547-56. 
PMID: 10609777 

44: Maksimenko AV, Tischenko EG, Golubykh VL. 
Antithrombotic activity of the superoxide dismutase-chondroitin sulfate complexes in a rat model of arterial injury.
Cardiovasc Drugs Ther. 1999 Nov;13(6):479-84. 
PMID: 10686656 

45: Nishikawa M, Igarashi R, Nakazawa T, Aikawa E. 
Rescue of (NZB x NZW) F1 mice from oxygen-derived free radical injury by use of phosphatidylcholine-modified superoxide dismutase.
Lab Anim Sci. 1999 Oct;49(5):560-4. 
PMID: 10551459 

46: Yavuz Y, Yuksel M, Yegen BC, Alican I. 
The effect of antioxidant therapy on colonic inflammation in the rat.
Res Exp Med (Berl). 1999 Oct;199(2):101-10. 
PMID: 10550643 

47: Corvo ML, Boerman OC, Oyen WJ, Van Bloois L, Cruz ME, Crommelin DJ, Storm G. 
Intravenous administration of superoxide dismutase entrapped in long circulating liposomes. II. In vivo fate in a rat model of adjuvant arthritis.
Biochim Biophys Acta. 1999 Jul 15;1419(2):325-34. 
PMID: 10407083 

48: Kondo T, Terajima H, Todoroki T, Hirano T, Ito Y, Usia T, Messmer K. 
Prevention of hepatic ischemia-reperfusion injury by SOD-DIVEMA conjugate.
J Surg Res. 1999 Jul;85(1):26-36. 
PMID: 10383834 

49: Garcia-Gonzalez A, Ochoa JL. 
Anti-inflammatory activity of Debaryomyces hansenii Cu,Zn-SOD.
Arch Med Res. 1999 Jan-Feb;30(1):69-73. 
PMID: 10071429 

50: Nguyen WD, Kim DH, Alam HB, Provido HS, Kirkpatrick JR. 
Polyethylene glycol-superoxide dismutase inhibits lipid peroxidation in hepatic ischemia/reperfusion injury.
Crit Care. 1999;3(5):127-30. Epub 1999 Sep 23. 
PMID: 11056736 

51: Davis JM. 
Superoxide dismutase: a role in the prevention of chronic lung disease.
Biol Neonate. 1998 Sep;74 Suppl 1:29-34. Review. 
PMID: 9730589 

52: Lamproglou I, Magdelenat H, Boisserie G, Baillet F, Mayo W, Fessi H, Puisieux F, Perderau B, Colas-Linhart N, Delattre JY. 
An experimental model of acute encephalopathy after total body irradiation in the rat: effect of liposome-entrapped Cu/Zn superoxide dismutase.
Int J Radiat Oncol Biol Phys. 1998 Aug 1;42(1):179-84. 
PMID: 9747836 

53: Li X, Wang LJ, Tang N, Yue H, Huang Y, Lu J, Wang B. 
Effects of isovolumetric hemodilution treatment and superoxide dismutase on ischemic reperfused hearts in rabbit.
Clin Hemorheol Microcirc. 1998 Jul;18(2-3):157-63. 
PMID: 9699037 

54: D'Agnillo F, Chang TM. 
Polyhemoglobin-superoxide dismutase-catalase as a blood substitute with antioxidant properties.
Nat Biotechnol. 1998 Jul;16(7):667-71. 
PMID: 9661202 

55: Maksimenko AV, Tishchenko EG, Golubykh VL. 
[Antithrombotic activity of complexes of superoxide dismutase with chondroitin sulfate in arterial damage in rats]
Vopr Med Khim. 1998 Jul-Aug;44(4):353-61. Russian. 
PMID: 9845922 

56: Das S, Horowitz S, Robbins CG, el-Sabban ME, Sahgal N, Davis JM. 
Intracellular uptake of recombinant superoxide dismutase after intratracheal administration.
Am J Physiol. 1998 May;274(5 Pt 1):L673-7. 
PMID: 9612281 

57: Ambrosio G, Zweier JL, Becker LC. 
Apoptosis is prevented by administration of superoxide dismutase in dogs with reperfused myocardial infarction.
Basic Res Cardiol. 1998 Apr;93(2):94-6. 
PMID: 9601575 

58: Miyahara T, Shibamoto T, Wang HG, Koizumi T, Honda T, Kubo K, Sekiguchi M, Koyama S. 
Lecithinized superoxide dismutase attenuates phorbol myristate acetate-induced injury in isolated dog lung.
Eur J Pharmacol. 1998 Mar 5;344(2-3):231-9. 
PMID: 9600659 

59: Tu Q, Tang J, Shen L, Lei Y, Yu S, Zhou J, He J, Chen C, Zhang F, Zhang F, Dong F, Peng H, Tan H. 
[The second phase clinical observation of anti-radiation effect by superoxide dismutase]
Hunan Yi Ke Da Xue Xue Bao. 1998;23(3):308-10. Chinese. 
PMID: 10681768 

60: Baker K, Marcus CB, Huffman K, Kruk H, Malfroy B, Doctrow SR. 
Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury.
J Pharmacol Exp Ther. 1998 Jan;284(1):215-21. 
PMID: 9435181 

61: Gusev VA, Danilovskaia EV. 
[The influence of superoxide dismutase and catalase on the course of the pathological process in the lungs in experimental silicosis]
Med Tr Prom Ekol. 1998;(10):17-21. Russian. 
PMID: 9855741