Posted August 14, 2011 Disclaimer The information presented here is for informative and educational purposes only and is not intended as curative or prescriptive advice. This is work in progress.
The cause of obesity and losing body weight Gallard: American diet has been a controversy for over 40 years. Weight loss diets have not worked for most persons trying to lose weight! Hence, there is a lot of confusion and controversy about obesity and weight loss. The good news is that In 1994 researchers discovered a hormone made by the body itself that appears to have great promise in helping control our body weight! This article is about this new science discovery that many doctors and weight loss experts do not know about or have ignored!
"The problem with sliding down the slippery slope of slow and progressive weight gain over the years is that you may have a lot of trouble pulling yourself up and out of the hole. In fact, new science says you most likely caused brain damage by eating too much food. Such damage causes you to crave and eat what you know you shouldn’t." Richards: food cravings & brain damage This is a quote from an superb and simplified article by Richards about how leptin affects your body. You are urged to read it! Another simplified anonymous article is: Balancing leptin
99.99% of overweight people make too much leptin; however, the leptin does not get into the brain properly (leptin resistance), so they sort of behave like the person who makes no leptin at all.
Leptin, labeled the 'hungry hormone,' is a most powerful regulator that tells the brain what to do about life's two main biological goals: eating and reproduction. Your fat, by way of leptin, tells your brain whether you should be hungry, eat and make more fat, whether you should reproduce and make babies, or (partly by controlling insulin) whether to "hunker down" and work overtime to maintain and repair yourself. One could make a very convincing and scientifically accurate statement that rather than your brain being in control of the rest of your body, your brain is, in fact, subservient to your fat -- and leptin.
Below is a short video by Byron J. Richards introducing the hormone leptin.
It is just as important when you eat as what you eat! Watch Byron Richards, leading Leptin expert, explain The Leptin Diet 5 Rules, and why they are so important to follow for weight management and optimum health. "Learn how to eat in harmony with the hormone leptin."
Video: The Leptin Diet 10 mns
The video has no doubt aroused a lot of curiosity about leptin and weight loss. How real is this information about leptin? Below is the text version of the video. This will allow you to get more acquainted with the five rules of the leptin diet.
The Five Rules of the The Leptin Diet are: Richards: 5 diet rules
NOTE: Another medical doctor, Scott Isaacs, has his own version of how to lose weight and a lot of very good information about leptin. Isaacs: Leptin articles
Richards has a free e-newsletter, which will deliver breaking news on leptin, thyroid, and weight management right to your inbox.
To order the: Leptin Connection E-Booklet
Now for the "nuts and bolts" of leptin!
What is leptin?
Human leptin is a protein of 167 amino acids. It is manufactured primarily in the adipocytes of white adipose tissue. The level of circulating leptin is directly proportional to the total amount of fat in the body. In addition to white adipose tissue — the major source of leptin — it can also be produced by brown adipose tissue, placenta (syncytiotrophoblasts), ovaries, skeletal muscle, stomach (lower part of fundic glands), mammary epithelial cells, bone marrow, pituitary and liver. Wiki:Leptin
Leptin Function: Leptin acts on receptors in the hypothalamus of the brain where it inhibits appetite.
Our body has evolved to use a very efficient pair of hormones which signal the brain when it`s time to eat, or when we`ve had enough food. Leptin [ regulates brain appestat center ] and ghrelin [ signals pleasure eating and signals stomach’s craving for food ] are the hormonal messengers responsible for our desire to eat, our craving for certain foods and whether we store excess calories as body fat... Leptin news
What does Leptin do?
Leptin Regulates Metabolism And Appetite:
The number of calories you burn is regulated by thermogenesis, a process in which the body makes heat, mainly in the muscles. According to recent research from Monash University in Australia, the hormone leptin can substantially increase thermogenesis, helping to burn fat.
Research done at the Laval University in Quebec found that 7-8 hours of sleep each night, on average, was associated with relatively higher levels of leptin. In contrast, getting less sleep meant lower levels of leptin and higher body mass index in the study. Galland: Leptin diet works for you
There is some controversy regarding the regulation of leptin by melatonin during the night. One research group suggested that increased levels of melatonin caused a down regulation of leptin. However, in 2004, Brazilian researchers found that melatonin increases leptin levels in the presence of insulin, therefore causing a decrease in appetite during sleeping. Wiki:Leptin
According to the latest research, leptin plays an important role in appetite control, metabolism and weight loss. It is your body's natural weight control mechanism. And the great thing about leptin is that it is produced naturally in the body. Galland: Leptin diet works for you
How leptin works: "Leptin is known as the fat-hormone because it is made in your white adipose tissue, or stored fat. Following a meal leptin is released from your fat, enters your blood, and travels to your brain delivering a message that you are full and also letting your subconscious brain know how much fuel you have on hand (like the gas gauge in your car).
Leptin resistance: One of the simple-case leptin problems encountered by any person who is overweight is that the leptin "gas gauge" is sticky, and leptin is not entering your brain correctly (leptin resistance). This produces a false state of perceived starvation, meaning you feel hungry and your subconscious brain thinks your fuel tank is near empty, even though you have plenty of stored fat on hand. This causes you to eat more food than you really need to eat.
Because of today’s abundance of food, most people have developed leptin resistance. Leptin resistance causes the brain to ignore the signal of satiety sent by leptin, thus making us feel hungry even when we’re really full. Endocrinologist Scott Isaacs outlines the symptoms of leptin resistance: Isaacs: Symptoms of leptin resistance
You must keep leptin in a state of healthy balance for your metabolism to work correctly and your appetite to be under control. This is not a situation where you take leptin hormone as a substance. This is a situation wherein diet, exercise, lifestyle (stress management in particular), getting restful sleep, and various nutrients help to optimize the function of leptin in your body." Richards: supplements Balancing leptin
Key signs of a leptin problem include: Richards: Leptin books
Leptin is the way that your fat stores speak to your brain to let your brain know how much energy is available and, very importantly, what to do with it. Therefore, leptin may be "on top of the food chain" in metabolic importance and relevance to disease. Rosedale: Health disease & aging
For the girl on the left, her hypothalamus is correctly sensing leptin and maintaining her body with normal weight, while for the girl on the right, her hypothalamus is not correctly sensing leptin and therefore, her body cannot lose weight, but continues to store fat, virtually regardless of how little she eats or how much she exercises.
Eating too much, eating too late in the evening or at night, snacking between meals, lack of exercise, and stress can all cause health problems by disrupting the function of leptin:
These factors have now been proven regardless of a person's body weight. Conversely, proper leptin function is highly protective of all factors relating to cardiovascular health. Richards: Leptin books The treatment of cardiovascular disorders needs to seriously consider the affect leptin has on the body.
Those individuals who make a habit of eating late at night are on a fast track to accelerated aging, poor sleep, and poor health. This is not a fad diet, this is the new science – and every person needs to understand what it is all about. Richards: Leptin books
Hugely obese children have been found who have an inability to lose weight due to a genetic inability to produce leptin. Injections of leptin have had dramatic weight loss effects. It appears that, if one cannot make leptin, the brain thinks there is no fat and spurs the person on to eat more and more in a futile effort to get the leptin signal that fat is present. However, the effect of leptin on people who are obese but can make leptin normally appears to be different.
Leptin in relation to demographics: Leptin levels in healthy women are substantially higher than in healthy men. The third National Health and Nutrition Survey (NHANES III) conducted by the National Centre for Health Statistics of the Centres for Disease Control and Prevention (CDC), involving randomly selected 3366 women and 2937 men aged≥20 years, found that the mean serum leptin level was much higher in women (12.7 μg/ L) than in men (4.6 μg/L). Also leptin levels were shown to be significantly higher in non-Hispanic blacks than in non-Hispanic whites of both sexes, and Mexican Americans had concentrations that were intermediate. Singh: CVD risk
Measuring leptin level in your body:
According to Dr. Scott Isaacs, M.D., author of "The Leptin Boost Diet" and "Hormonal Balance" by Byron Richards M.D., there is no effective test to measure leptin levels or resistance, but other tests or markers are used to determine leptin resistance levels. Russell: checking leptin level Check these articles for suggestions on how to evaluate your leptin level. Measuring leptin Russell: checking leptin level
Getting a leptin test: These is controversy between the two
experts on leptin [ who say there is not reliable test at this time ] and the
lab companies [ who espouse lab tests ]. High-tech research labs are currently investigating
different tests to determine how accurately each calculates blood leptin levels.
One such test, called the Competitive ELISA Kit, has shown promise as a possible
accurate measure of blood leptin levels. According to the American Physiological
Society, high levels calculated by that method were strongly correlated with
decreased weight, while low levels were found in heavier individuals.
Potential Factors that Raise Leptin Levels: Douglas labs
Nutritional Supplements That Can Help Lower Leptin Levels: Douglas labs
ALERT: This is clinical information intended for medical doctors and labs.
The conclusion of researchers [ see references ] about leptin is that leptin affects our appetite, metabolism and can be a major cause of disorders and diseases or good health. There is a definite lack of awareness about leptin by the general public and lack of understanding by medical doctors. Leptin's critical importance is largely unknown to the medical community because there are no known drugs that regulate its activities and therefore there is no incentive to spend money to educate doctors about leptin's crucial role in health and disease. Mercola: diabetes obesity link to leptin Rosedale: Health disease & aging This does not lessen the need of doctors to know about leptin!
In spite to public ignorance, there is scientific proof that leptin does regulate appetite and body metabolism. Leptin can help with obesity and general health. We all need to rethink how the body is regulated and how we may improve our health.
Public education needs to re-focus on the new concepts of what, how and when we eat. And we need more good research about leptin, nutrition and optimal well-being.
The eating-diet principles suggested by Richards are guided by the affects of leptin on the brain and body. This approach is based on science and common sense and has more merit than the experimental diets suggested by weight loss proponents. But not everyone following the Richards will lose weight. Those wishing to lose weight will need will-power, desire and discipline to lose weight. Just knowing about the Richards 5 step diet is not enough!
We need to re-shape and re-design how we live. Research tells us that Americans have sloppy lifestyles that make them 'fat' sick: "We are in denial. 9 out of 10 people believe they eat a healthy diet. Compared to 100 years ago, Americans consume 62% more meat, 870% more cheese, 1600% more frozen dairy products and 2400% more oil. On any given day, 95% of Americans do not exercise. According to researchers at Yale University, 84% of parents take their children to a fast food restaurant at least once a week." Isaacs: Leptin articles
By ignoring the leptin recipe for good health, we inadvertently make ourselves sick. We need to eat in harmony with leptin. We need to identify reinforcements for good lifestyle from our loved ones, your friends and even the government. Make friends with those that make you a better person! Abandon your bad habits for leptin habits! You need to change!
Alert: You should also check out how toxins can interfere with obesity. [scroll to "toxins interfere with weight loss ]
Flirting with hormones on your own is like playing with dynamite. Like dynamite, your hormones can get out of control and "***BOOM.***" Change under the guidance of a medical doctor.
"Balancing Leptin - the Hunger Hormone - Frequently Asked Questions." Balancing leptin
Braverman Eric R., MD, "The Role of Leptin," Douglas labs, NutriNews. Douglas labs
Chung CP, Long AG, Solus JF, Rho YH, Oeser A, Raggi P, Stein CM, "Adipocytokines in systemic lupus erythematosus: relationship to inflammation, insulin resistance and coronary atherosclerosis," Lupus. August 18,)2009:799-806. Chung: leptin affects lupus
In conclusion, patients with SLE have increased concentrations of adiponectin, leptin and visfatin. Lower concentrations of adiponectin and higher concentrations of leptin are associated with insulin resistance, BMI and CRP in patients with SLE.
Galland Leo, M.D., "The Standard American Diet (SAD)," Pill Advised. Gallard: American diet
El-Badawy Reda Mohammed, Abdullah Saeed Al-Ghamdi, Ibrahim Abdulkarim Al-Mofleh, "Concepts in leptin and liver disease," The Saudi Journal of gastrology, 2004 Volume: 10 Issue: 2 Page : 57-66. El-Badawy: cirrhosis "circulating leptin level are increased in cirrhosis, hepatitis C virus (HCV) and non-alcoholic steatohepatitis (NASH)"
Ha Kim, Choi GS, Jeon JY, Yoon JM, Sung JM, Suh CH. "Leptin and ghrelin in Korean systemic lupus erythematosus," Lupus, February 19, 2010 (2):170-4. Ha: Leptin - Lupus in Korea
Abstract: Elevated serum leptin levels have been described in patients with systemic lupus erythematosus (SLE), however these studies have provided no information regarding the ghrelin levels. We investigated the clinical significance of serum leptin and ghrelin levels in SLE. The leptin levels of SLE patients were higher than those of normal healthy controls, while the ghrelin levels of the SLE were lower. In addition, the ghrelin levels were significantly lower in SLE patients with arthritis and hematologic disorder. Taken together, these findings suggest that leptin and ghrelin play a role in clinical manifestations observed in SLE.
"How to Measure Leptin." Measuring leptin
Hu F B, C Chen, B Wang, M J Stampfer and X Xu, "Leptin concentrations in relation to overall adiposity, fat distribution, and blood pressure in a rural Chinese population," International Journal of Obesity, January 2001, Volume 25, Number 1, Pages 121-125. Hu: leptin in Chinese
"We observed a strong positive relationship between overall adiposity and leptin levels in both men and women in a rural Chinese population. In addition, leptin concentrations were significantly associated with central obesity measured by waist to hip ratio and abdominal skinfold, independent of overall obesity."
Isaacs Scott M.D., "Recent Articles By Scott Isaacs M.D.," Joined Ezine Articles, Dec 7, 2010. Isaacs: Leptin articles
Isaacs Scott M.D., "Leptin Not Working?" Ezine Articles. Isaacs: Symptoms of leptin resistance
Kam Katherine, "The truth about the hormone leptin and obesity," WebMD, Reviewed by Laura J. Martin, MD Kam: leptin & obesity
Leptin news, articles and information: Natural News, September 17, 2010. Leptin news
Mercola , "Leptin: How Diabetes and Obesity Are Linked," Mercola.com, April 02 2005. Mercola: diabetes obesity link to leptin
"Research on mice has suggested that eptin is the key, as it regulates blood sugar through two different brain-body passageways:
Leptin related health issues related to lupus, US National Library of medicine, Leptin-lupus articles
Richards Byron J., "Are Food Cravings and Excess Food Consumption a Sign of Brain Damage?" Byron J. Richards Wellness resources, July 12, 2011. Richards: food cravings & brain damage
Richards Byron J., "Leptin and Weight Management Supplements," Byron J. Richards Wellness resources Richards: supplements
Richards Byron J., "The Five Rules of The Leptin Diet®," Weight Loss News, January 12, 2009 Richards: 5 diet rules
Richards Byron J., "THE LEPTIN DIET: Five Simple Rules for Healthy Weight Loss," Mastering Leptin, The Leptin Diet, Wellness Resources Books, Minneapolis, Mn..
"how leptin problems cause cancer, fibromyalgia, thyroid problems, heart disease, and of course - obesity Leptin problems are now fully proven to be the primary cause of heart disease, including high cholesterol, high blood pressure, circulatory inflammation, and hardening of the arteries. These factors have now been proven regardless of a person's body weight. Conversely, proper leptin function is highly protective of all factors relating to cardiovascular health. when a person eats is actually more important than what they eat. Snacking turns out to be one of the most harmful eating habits. Those individuals who make a habit of eating late at night are on a fast track to accelerated aging, poor sleep, and poor health. This is not a fad diet, this is the new science – and every person needs to understand what it is all about." Richards: Leptin books
Rosedale Ron, "Leptin -- Its Essential Role in Health, Disease, and Aging," Rosedale: Health disease & aging
Rosenbaum M et. al. Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab (2002) 87:2391-2394.
Russell Lisa M., "How to Check Leptin Levels," EHow Health, Russell: checking leptin levelWarning:
Singh Mukesh ⁎, Updesh S. Bedi, Param P. Singh, Rohit Arora, Sandeep Khosla, "Leptin and the clinical cardiovascular risk," International Journal of cardiology, November 27, 2009. Singh: CVD risk
Singhal Atul, MD, I. Sadaf Farooqi, Tim J. Cole, Stephen O’Rahilly, Mary Fewtrell, Mia Kattenhorn, Alan Lucas, MD, John Deanfield, "Influence of Leptin on Arterial Distensibility: A Novel Link Between Obesity and Cardiovascular Disease?" July 24, 2002. Singhal: Leptin CVD link
Testimonial by LaDawn July 21st, 2010: "I have been on the Leptin Diet for three weeks and am averaging 3 pounds per week. I have a lot of hormone problems, hypothyroid, hashimotos, female hormones and this diet has worked wonders for me. I felt starved on the South Beach diet and just found it impossible. I have never had a diet work for me like this one. I think the food portions and not eating between meals has worked wonders for me! Might not be for everyone but if you have hormone troubles..this is the diet for you! I also had adrenal disorder two years ago and finally now am feeling great. I was very, very ill for two years and now feel so much better. It also helps the Fibromyalgia a lot. If you have Fibromyalgis…get his Mastering Leptin book too. Both are best as the the Mastering Leptin can get into some heavy stuff and the paperback short version is a good read and simple to understand!" Richards: Leptin books
U.S. National Library of Medicine, "Obesity," National Institutes of Health, 1998. US Library of medicine
Wikipedia Leptin Wiki:Leptin