Nutrition information often not scientifically data based 
By Walter Sorochan  Emeritus Professor: San Diego State University

Date posted: September 14, 2012; updated March 14, 2013.   Disclaimer   

Abstract: 

A review of how decisions are made about nutrients and their recommendations to the public. Many nutritional recommendations, like recommended dietary allowances and guidelines, are often made on speculation, expert opinion and guesses instead of good science!. Many researchers in the past used inappropriate designs to study nutrition and health. Scientists evolve nutritional guidelines that often overlook individual biochemical differences among people, foods grown on eroded soils having low mineral content, lack of adequate information about nutritional co-factors, and so on.  We desperately need more, better and independent research about nutrition and health.

Introduction 

evidenceapples oranges For the past 50 years we have been bombarded with information about nutrition, what to eat and how much.  Much of the data to support nutritional recommendations [ e.g. Recommended Daily Allowances/Intake (RDA/I) ] lack scientific evidence and is based on speculation, expert opinion and guesses.  O'Shea: Minerals  [ Recommended Daily Intake (RDI) is the daily intake level of a nutrient that is considered to be sufficient to meet the requirements of 97–98% of healthy individuals in every demographic in the United States.]  Indeed, the identity of 'the science' itself has eroded in the past 50 years.  This erosion has occurred in spite of many technological advancements in industry, medicine and the health fields. "The scientific revolution has stalled!" Myslewski: science stalled 2013  Scientific Integrity 2012 Robinson: Govt corrupts science 2010  The lack of focus on relevant research in health and nutrition perceived as a consequence of this revolution. 

Recent scientific advances on nutrition have not led to consensus, but rather to substantial disagreement among experts and further uncertainty for the public. Hite: weaknesses in guidelines 2010   Taubes: epidemiological studies on health 2007  The value of RDA/RDIs is disputed among nutritionists. Hanson: dumb RDA 2011  Indeed, even the "definition of RDAs and their relevance to health" is disputed.  Henney: failure to change habits 2010   HBP com: 1999 Wiki: RD 

Although nutritionists and those selling nutritional supplements espouse that they have all the information needed to convince you that they know what they are saying and doing, this may not be the case!

Such controversies makes it appropriate to review the processes of how decisions are made about nutritional values.

Appropriateness of nutritional research design studies 

 We lack good research on food, nutrients and health. 

Nutritionists hide behind the idea that information about nutrition is scientifically based. But there is now information from respected researchers that all decisions about nutrition are not based on real evidence data and good research. Hanson: dumb RDA 2011  Borger: drug monopoly During the last decade, approaches to evidence-based medicine, with its heavy reliance on the randomized clinical trial [RCT], have been adapted to nutrition science and policy. However, there are distinct differences between the evidence that can be obtained for the testing of drugs using RCTs and those needed for the development of nutrient requirements or dietary guidelines. Hildenbrand: nutrition as preventative

There have been numerous other instances in recent decades when individuals or groups of individuals have advocated nutritional interventions or alternative dietary lifestyles as a means of preventing or even treating disease and have met not only indifference but often hostility. This was especially true for those advocating vegetarianism or an extremely low-fat diet as a means of preventing or treating illnesses such as heart disease.  Hildenbrand: nutrition as preventative

Respected author Gary Taubes has summarized the many prospective or cohort and randomized-controlled trials research studies, of which the renown Harvard University Nurses’ Health Study is among the most respected. He reviews various aspects of the Nurse's Health Study on how epidemiological analyses [ comparisons of populations with and without a disease ] have concluded that medical researchers make flawed conclusions about cause and effect based on circumstantial evidence; thereby often drafting invalid recommendations and public policies. Confounding effects also limit the credibility of research trials and this is often overlooked. Taubes: epidemiological studies on health 2007  Ben Goldacre: drug ghosts bad science 2010 Borger: drug monopoly

Nutrition and chronic disease research is actually in a relative state of infancy compared to that for pharmaceuticals, which has long adhered to the principles of evidence-based medicine [EBM]. In contrast to pharmaceuticals though, nutrition researchers have yet to establish clear criteria and guidelines for how best to study the effects of nutrients in humans, and subsequently how to evaluate those findings, i.e. what constitutes ‘evidence-based nutrition’ (EBN).   Shao: evidence nutrition 2009

Several prominent nutrition researchers have been quite vocal in recent years, raising concerns over what they perceive to be the misapplication of drug-based trials to assess nutrition questions. Shao: evidence nutrition 2009  What is the difference between drugs and nutrients?  Drugs generally have effects on single cells in the body whereas nutrients tend to work in concert with other helper nutrients and affect multiple cells and organs. Since drugs affect body systems differently from nutrients, the traditional “gold standard” research design used in evaluating drug medications is not applicable to evaluating nutrient affects and dosages. It is helpful to briefly review how the daily intake level of vitamins and minerals is determined.  Shao: evidence nutrition 2009  Taubes: epidemiological studies on health 2007

How we get information about food and health

There is a lot of information on the internet that is of questionable quality.  Reporters often tend to hurry their scripts in an effort to meet deadlines.  Hence mass media information about nutrition is not very reliable.

There is also mounting controversy over how dietary recommendations are made:

  • current Dietary Recommended Intakes (DRI’s) were largely based upon opinion instead of randomized controlled clinical trials Wiki: Diet Ref Intake 2012
  • the definition of RDAs and their relevance to health" is disputed. Henney: failure to change habits 2010  HBP com: 1999  Wiki: RDI
  • many nutrition recommendations that have no scientific supporting evidence have been and are still being given to individuals with diabetes. Franz: Diabetes RDA 2002
  • A shortage of credible information exists on practical dietary and physical activity patterns that have potential to reverse the national obesity epidemic and reduce the risk of major cancers and other chronic diseases. Prentice: Nutrition & cancer 2004
  • a consensus of expert opinion based on current knowledge and best practices was used to formulate procedures as to how nutrients are delivered to the gastrointestinal tract by way of a tube or catheter to the stomach or other part of the digestive system [ process referred to as Eternal Nutrition ].  Bankhead: IV nutrition 2009
  • medical consensus --- even when it represents the honest opinions of the most knowledgeable, leading scientists in the field ---- has clearly been wrong. Hildenbrand: nutrition as preventative
  • The general pattern of the Dietary Guidelines Advisory Committee [DGAC] Report: strong recommendations are made with weak and inconclusive evidence to support them. Hite: time to reexamine RDI 2010 

Bad medical-drug research

Flawed drug research designs have been unwittingly used as models for studying nutrition and health. Angell: truth about drug companies 2010  Ben Goldacre: drug ghosts bad science 2010  Borger: drug monopoly   Messina: nutrition research 2011  The public puts its trust in drug related studies on the assumption that the federal government is a watch dog in such research, and supposedly monitors and polices an equal playing field in medical-drug research.  More important, the public assumes that products of such research are safe medications that doctors prescribe.  Instead, doctors who prescribe these drugs are doing so on faulty information.  Unfortunately, the federal government has failed to police a fair and honest research playing field; one that is tilted toward private drug companies and not the safety of the public Those conducting nutritional-health research are lulled into believing that drug research designs are the designs that they should use. 

 British medical doctor and researcher Ben Goldacre Moosa: Shody med research 2012 discusses the ways pharmaceutical companies conduct medical trials on drugs. He continues:

"Drugs are tested by the people who manufacture them, in poorly designed trials, on hopelessly small numbers of weird, unrepresentative patients, and analyzed using techniques that are flawed by design, in such a way that they exaggerate the benefits of treatments. Unsurprisingly, these trials tend to produce results that favor the manufacturer.

This means negative results, alternative or incredibly bad side-effects, comparisons to other trials with larger, more varied sample sizes, are all being ignored or glossed over. What does this mean for us, as non-medical people? It means our doctors who prescribe these drugs are doing so on potentially faulty information — on evidence massaged into truth by the same hands that also hold the broader context behind their backs."  Moosa: Shody med research 2012

In spite of revealing information about how unreliable drug research designs may be, many nutrition and health researchers perceive drug research designs as the model to emulate.   Adding to the grief of copycatting bad research designs is information that recommended eating guidelines for many disorders, like diabetes, obesity and cardiovascular diseases, are often based on opinions of persons and to a lesser degree on data-driven nutritional research.  Such opinionated recommendations may be further distorted by bad research. Angell: truth about drug companies 2010  There is also the report by reporter Ben Goldacre that drug companies have employed ghost writers to produce academic papers that can be printed in academic journals to build a brand message.   The falsified drug information is sanctified as published in a reputable academic journal, then made public. Ben Goldacre: drug ghosts bad science 2010  Angell: truth about drug companies 2010 

Another aspect of nutrition research is lack of good communication by researchers.  The research may be good but the information provided to the public is often poorly done by mass media.  Hence, the public becomes poorly informed. Miller: nutrition communication

Intent of Nutrition Guidelines

The evolution of nutritional guidelines is another example of how unreliable nutritional recommendations can be. Recommended Daily Allowances were not meant to be guidelines for consumers; they were originally designed to serve as standards for planning food supplies for population groups [National Research Council, 1989]. However, they are used as a partial basis for the development of other guidelines that are intended for consumers, such as the Food Guide Pyramid, which was released by USDA in 1992 to replace the old "basic four" food groups. Hildenbrand: nutrition as preventative

Most knowledge about nutrition and staying healthy came incidentally from observation of whether persons were sick or healthy.  Below are four such examples:

Vitamin C:  British sailors dying on long ocean voyages was a mystery over 200 years ago.  Their bodies seemed to become unglued, they had bleeding gums, their teeth would become loose and fall out, they felt severe pain in joints and suffered from extreme fatigue!  It was observed that sailors on long voyages did not have access to fresh fruits or vegetables [ which contained vitamin C ].   By coincidence, some sailors were fed lemon juice and this, in turn, linked them from dying from scurvy.  Ship captains came to realize that lemons could be stored for a long time and prevent British sailors from getting sick and disabled during long sailing voyages.  The symptoms of long ocean voyages was labeled scurvy. 

The minimum amount of vitamin C in the lemons needed to just prevent scurvy was somewhere between 20 - 40 mgs per day per person.  More revealing, this minimum amount was incorrectly assumed and adopted as the minimum amount of vitamin C needed for good health.   Expert scientists came on the scene 40 years ago and raised this minimum amount to 60 mg per day and called it Recommended Daily Allowance [RDA]; ignoring the vitamin C research of Linus Pauling. Kaplan: R. Williams Bichem individuality 2012   Recent increase of vitamin C from 70 mg to 90 mgs on the basis of expert opinion is still an unknown amount for optimal health.    

The point here is that the original amount of recommended vitamin C was not based on scientific research!

The current test for vitamin C is a serum C test.  It assesses the vitamin C content in the blood but not in the other tissues of the body!  "Serum C does not and will NOT reflect tissue levels.  What tissues? Every tissue, every cell in your body, skin, muscle, bone, teeth, all organs, pituitary, adrenals, heart, kidney, liver, ovaries, testes, and your brain, contain and require vitamin C."  Unfortunately your tissue levels cannot be tested until you're dead. You need to take vitamin C and experiment for the best dosage for you. Krispin: vit C revisited 2011  The uses and the daily requirement amounts of vitamin C are matters of on-going debate."From recent research [and looking back to the wisdom of early researchers and scientists including Stone, Klenner, Jungeblut, Cathcart, Cameron, Pauling, and more recently Hickey and Riordan] vitamin C isn’t just a vitamin anymore and 100 mg a day is not enough for short or long term health at any age, size, ethnicity or location. Krispin: vit C revisited 2011 

Vitamin D: The story of the discovery of scurvy, cause, and treatment, is also similar to the story of rickets and vitamin D.  For vitamin D deficiency [rickets] cod liver oil restored health if given before permanent deformations occurred and eventually it was determined that the active ‘cure’ in the cod liver oil was vitamin D, the same D produced in human skin exposed to UV-B light. What is also similar between the history of vitamin D and vitamin C is the healthcare doctrine of ‘if you don’t die or deform quickly’ you have enough.  In other words, the amount of vitamin D needed is based on the minimum needed to prevent rickets!" What do I [Krispin] mean? 400 IU of vitamin D will certainly prevent rickets in most cases [not all] and until quite recently it was the ‘Gold Standard’ for sufficiency."  However, after years of clinical research supporting a multitude of other roles for vitamin D, besides avoiding rickets, a much greater amount, up to 4,000 IU daily, is now recognized as possibly being needed for short and long term health.  Krispin: vit C revisited 2011

The dosage recommendation from the Vitamin D council, headed by executive director and researcher John Cannell, is supported by the most recent research over that proposed by US Office of Dietary Supplements. There is no consensus about the appropriate reference range and cut-offs for deficiency or insufficiency, as well as optimal and possible toxicity status.  Rollins Vit D testing |Vit D Council Min dosage

Salt [Sodium]:

The controversy over the amount of salt needed for good health is another example of flawed decision making.

According to Mr. Morton Satin, Vice President of Salt Institute’s Science and Research, Salt Institute: 2006  there are several prestigious institutes that are responsible for the salt guidelines. These include, the Institute of Medicine, the Center for Disease Control, and the National Heart, Lung and Blood Institute (NHLBI) to name a few.  These are the research organizations that set the standard. Then there are the activism organizations such as the World Action on Salt and Health (WASH) and the Consensus Action on Salt and Health (CASH).  Although not surprisingly, these organizations have many of the same people involved, who are also doing the research. Real Food Forager: salt delusion 2012  Hite: time to reexamine RDI 2010

The Intersalt study was a huge multifaceted study that looked at the relationship between salt intake and blood pressure. The researchers concluded that high salt intake is “causing the unfavorable population-wide blood pressure pattern that is a major risk factor for epidemic cardiovascular disease.”   However, according to Morton Satin, their statistics were skewed.  The bottom line is that the Recommended Daily Intake [DRIs] for salt were arbitrarily set. The officials admitted that because of insufficient data, an estimated requirement could not be established. Hence they provided one. Totally arbitrary. Real Food Forager: salt delusion 2012  "The zealous drive by politicians to limit our salt intake has little basis in science."  Moyer: end salt war 2011 

Iodine

Iodine is a special situation that has a history of scientific, medical and political hypocrisy and controversy!  The medical perception of body requirement for iodine is based on the amount of iodine needed to prevent goiter and goes back to 1924. The normal daily requirement of the body for iodine has never been determined. Abraham: Orthiodinesupplementation  In this absence, the optimal daily requirement for iodine has been estimated at 6 mg of iodide for the thyroid gland and 5 mg of iodine for the mammary glands. [ two different forms of iodine ]  The point here is that majority of doctors perceive that iodine is needed only to prevent goiter! The amount needed to prevent goiter is not the same as the amount needed for the rest of the body organs and tissues. Schachter: Iodine role  Every cell in the body needs iodine and this is not understood by the medical profession. Many health disorders are due to lack of adequate iodine in the tissues. This is a most serious oversight!

Biochemical differences overlooked in RDA

Nutritional recommendations tend to ignore biochemical differences in people.  "One size does not fit all!"  The same amount of a nutrient [ e.g. 100mgs vitamin C per day ] does not fit the average all! Biochemical Individuality  Kaplan: R. Williams Bichem individuality 2012  As individuals of differing age, size and sex, we need different amounts of nutrients ---- one dosage for all does not fit all!

“The Recommended Dietary Allowances [RDAs], which were adopted by the Food and Nutrition Board of the National Research Council to establish the nutritional needs of "practically all healthy people," were not based upon the more recent information concerning the range of biochemical individuality among individuals.  The RDAs that describe "normal" nutritional needs have questionable relevancy to the concept of optimal nutrition based upon individual needs." Kaplan: R. Williams Bichem individuality 2012

Soil depletion - lower nutrients in food 

The affect that soils depleted of minerals have on plant food are seldom accounted for in RDI.  You don't know the real nutrient values in the foods you buy in the grocery store or the meals you eat in the restaurants.  Much of the food we eat is grown in soil that has been stripped of its mineral content. Although trace minerals are naturally found in topsoil, flooding and over-irrigation, along with poor crop rotation, have eroded topsoil, affecting the mineral content of our foods. Karr: Mineral nutrient depletion  Davis: decline in nutrients 2009  Marler nutri values from soils 2006  Butler: soil depletion 2006 Dairy Herd news: mineral absorption 2011  Laibow: nutrition & health

"According to Donald R. Davis, a former research associate with the Biochemical Institute at the University of Texas, Austin: the average vegetable found in today's supermarket is anywhere from 5% to 40% lower in minerals [including magnesium, iron, calcium and zinc] than those harvested just 50 years ago. Davis: decline in nutrients 2009

min content veggies
Marler nutri values from soils 2006

Co-Factors 

There is also a great information gap between what is known about how minerals and other nutrients work as helpers in the body [ also referred to as co-factors].  The alarming thing about co-factors is how important these are to absorption and utilization of nutrients and that so very little research is being done about co-factors.

Known mineral interactions include copper-molybdenum, sulfur-selenium, calcium-phosphorus, calcium-zinc, calcium-manganese, iron-manganese and potassium-magnesium. With many minerals, absorption of the mineral decreases as their amount in the diet increases. You also need to note that older humans typically have lower absorption rates. Schroeder: Minerals in cattle 2012  Dairy Herd news: mineral absorption 2011  Patton: Chelated minerals review 

Although the above mineral interactions may appear to be working, the exact ratio of co-factors to each other is unknown in many instances and may actually cause disorders. For example, how much calcium should be taken at the same time with magnesium?  The co-factor ratio of [ calcium ] Ca:Mg [ magnesium ] is not a precise ratio. One source suggests a Ca:Mg = 1:1 ratio, based on archeological studies of how man ate and survived over the past 10,000 years.  Another source, based on incomplete research, suggests that the ratio may be closer to 2:1 ... that is, for example 1000 mg of calcium to 500mg of magnesium.  Both ratios take into account that too much magnesium causes diarrhea and, on the other hand, that too much calcium may cause kidney stones and calcification in different parts of the body. These ratios may also be compromised by biochemical individuality. Co-factors  More often than not, co-factor ratios are expert guesses.

Bioavailability 

Another issue about nutrients is the amount of a nutrient that is absorbed from the digestive system. The amount of a nutrient ingested and the amount absorbed into the blood stream are two different quantities! You may ingest 100 milligrams of a nutrient supplement but the actual amount absorbed into the blood stream is unknown; probably about 10 to 30% actually enters the blood stream and varies with each individual.

The body often places control, even absolute limits on the percent of absorption that is possible for different minerals. For example, growing children can absorb up to 60% of their dietary calcium, whereas adults average only about 30% calcium absorption. Minerals are usually combined [ bonded or chelated ] with amino acids or citrates to facilitate absorption. Patton: Chelated minerals review  Such bonding is done to have better absorption in the digestive system.

In light of the limitations of nutrient availability to the body and with biochemical individuality among the public, commercial companies use educated guesses in designing supplemental formulations. Gerber: Mineral absorption  Garrett: mineral absorption 2011

Other Unknowns 

There are many other nutrient linked factors that have not been covered: such as the impact processed foods and genetically engineered foods have on quality and safety of nutrients in the foods we eat. The complete nutritional information on the label may be missing and is questionable!  Another is the controversy over the impact that fall-out radiation from nuclear power plant failure in Japan has on safety of sea foods.

Summary

This article reviewed the many aspects of how decisions are made about nutrients and their recommendations to the public. The revelations are not good. Many researchers in the past used inappropriate designs to study nutrition and health.  Too many recommendations have been based on expert opinions instead of good science! We desperately need more and better independent research about nutrition and health. Felder: professor research myth

Does inappropriate research in the past mean that research to improve human health is futile? Not at all.  Although nutritional guidelines may be the best information about nutrient values we have at this time we lack validity about nutrient quality and quantity. Of great concern should be the amount or dosage needed for super health and not just preventing diseases.  Many previous research attempts have provided us with some good information.  But we can and must do better! We need to demand more from those doing research.

We need to use appropriate and independent research designs to study nutrition, foods and health.  Research on nutrients needs to be independent of the regulatory subsidies of the Department of Agriculture, the drug corporations and the revolving doors of the FDA. 

The RDI claims made on nutritional labels should be viewed as approximate values. RDIs and supplemental information are unreliable and should not be trusted!  /span> 

While we wait for politicians and 'experts' on eating to get their act together and do a better job of researching about RDI and co-factors, we continue to eat and live!  Unfortunately, our foods, grown on depleted soils, are providing us with poor nutrition. The best source of all nutrients is still from food, buttressed by supplements. Suggesting that you use common sense in eating good food is easy but incorporating common sense into everyday life is difficult!  We need to re-engineer our life styles.  How we grow food and how we eat! 

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References: 

Abraham Guy. E. M.D., Jorge D. Flechas M.D. and John C. Hakala R.Ph., "Orthoiodosupplementation: Iodine Sufficiency Of The Whole Human Body," Abraham: Orthiodinesupplementation  "Based on the information previously discussed, the optimal daily I intake for I sufficiency of the whole human body would be equivalent to 2 drops of Lugol solution. In the USA, the initial implementation of I supplementation at this level would require medical supervision."

Angell Marcia "The Truth About Drug Companies," Mother Jones, December 10, 2010 [ A Interviewed By Peter Meredith of Mother Jones ]   Angell: truth about drug companies 2010

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"Biochemical Individuality," WellnessTips.  Biochemical Individuality

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Borger Julian, "Pharmaceutical Monopoly versus Free Market: Special Privilege Industry Full of Power," London Guardian, Borger: drug monopoly ""The PhRMA doesn't need to lobby," Democratic congressman Sherrod Brown said in a memo to staff last month. "The industry is in the White House already."Borger: drug monopoly

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Codex Alimentarius Commission (CAC), "Codex Guidelines History," July 2005.  Guidelines for Vitamin and Mineral 2005 The Codex Draft Guidelines for Vitamin and Mineral Food Supplements (Guidelines) document is on the agenda for finalization by the Codex Alimentarius Commission (CAC) at the July 2005 sesson in Rome.

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"Approximately 75 percent of dietary sodium is added to food during its processing and manufacturing. Only 10 percent of dietary salt comes from foods' natural content. Therefore, a high dietary salt intake is associated with diets in which a large portion of the daily calories consists of processed foods. Conversely, diets that have a higher proportion of fruits, vegetables, and legumes are associated with lower blood pressures. They also are consistent with current public health recommendations for diets, including the 1990 Federal Government's Dietary Guidelines for Americans. By following recommendations for lower sodium intake, consumers will encourage manufacturers of processed foods to expand the types and availability of lower sodium products. This should gradually reduce the sodium content of the U.S. food supply. Until then, consumers must be careful to select lower sodium products, especially among ready-to-eat cereals and certain other grain products."

Dairy Herd news source, "Factors that impact mineral absorption," Dairy Herd Network, December 20, 2011.  Dairy Herd news: mineral absorption 2011

Davis Donald R., "Declining Fruit and Vegetable Nutrient Composition: What Is the Evidence?" Journal of HortScience; February 2009, 5 pp. Davis: decline in nutrients 2009

Felder, Richard, "The Myth of the Superhuman Professor." J. Engr. Education, 82(2), 105-110 (1994).  Felder: professor research myth

Franz Marion J., and others, "Evidence-Based Nutrition Principles and Recommendations for the Treatment and Prevention of Diabetes and Related Complications," Diabetes Care, January 2002.  Franz: Diabetes RDA 2002

Gerber James, "A Review of Mineral Absorption with Special Consideration of Chelation as a Method to Improve Bioavailability of Mineral Supplements," Integrative Practitioner,   Gerber: Mineral absorption

Garrett Jack, "Organic minerals allow for greater absorption," Feedstuffs, July 11, 2011.  Garrett: mineral absorption 2011

Goldacre Ben, "Ghostwriters in the sky," The Guardian, September 18, 2010. Ben Goldacre: drug ghosts bad science 2010   British science writer, doctor and psychiatrist

"A commercial medical writing company is employed by a drug company to produce a programme of academic papers that can be rolled out in academic journals to build a brand message. After copywriters produce the articles, in collaboration with the drug company, to their specifications, the ghostwriting company finds some academics who are willing to put their names to them, perhaps after a few modest changes."

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Hanson Kassem, "RDA = Really Dumb Advice when it comes to Nutrition," FF in Blog, November 5, 2011.   Hanson: dumb RDA 2011

Henney Jane E., Christine L. Taylor, and Caitlin S. Boon, "Strategies to Reduce Sodium Intake in the United States," THE NATIONAL ACADEMIES PRESS, [Food and Nutrition Board] 2010.   Henney: failure to change habits 2010  Summary: "Activities to reduce sodium intake of the U.S. population have been ongoing for more than 40 years, but they have not succeeded."

Hildenbrand Gar and others, "Diet and Nutrition in the Prevention and Treatment of Chronic Disease,"  Hildenbrand: nutrition as preventative

Hite AH, Feinman RD, Guzman GE, Satin M, Schoenfeld PA, Wood RJ, "In the face of contradictory evidence: report of the Dietary Guidelines for Americans Committee," Nutrition, October 26, 2010;26(10):915-24. Abstract.

Hite: time to reexamine RDI 2010
"Important aspects of these recommendations remain unproven, yet a dietary shift in this direction has already taken place even as overweight/obesity and diabetes have increased. Although appealing to an evidence-based methodology, the DGAC Report demonstrates several critical weaknesses, including use of an incomplete body of relevant science; inaccurately representing, interpreting, or summarizing the literature; and drawing conclusions and/or making recommendations that do not reflect the limitations or controversies in the science."

Hite Adele H., Richard David Feinman, Gabriel E. Guzman, Morton, Pamela A. Schoenfeld, Richard J. Wood, "In the face of contradictory evidence: Report of the Dietary Guidelines for Americans Committee," Nutrition, 2010; 26, 915–924.   Hite: weaknesses in guidelines 2010

"DGAC Report demonstrates several critical weaknesses, including use of an incomplete body of relevant science; inaccurately representing, interpreting, or summarizing the literature; and drawing conclusions and/or making recommendations that do not reflect the limitations or controversies in the science. An objective assessment of evidence in the DGAC Report does not suggest a conclusive proscription against low-carbohydrate diets. The DGAC Report does not provide sufficient evidence to conclude that increases in whole grain and fiber and decreases in dietary saturated fat, salt, and animal protein will lead to positive health outcomes. Lack of supporting evidence limits the value of the proposed recommendations as guidance for consumers or as the basis for public health policy. It is time to reexamine how US dietary guidelines are created and ask whether the current process is still appropriate for our needs."

Kaplan Melissa, "Biochemical Individuality: The Key to Understanding What Shapes Your Health [re Roger J. Williams] Herp Care Collection, February 27, 2012. Kaplan: R. Williams Bichem individuality 2012

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Krispin, "Another Look at Vitamin C, Pauling was Right," Krispin’s Sporadic Newsletter, July 2011, Volume 2, Number 1.   Krispin: vit C revisited 2011

Human bodies need vitamin C in tissues which is impossible to test for. Vit C is tested in the body using the serum C test. "Serum C does not and will NOT reflect tissue levels. What tissues? Every tissue, every cell in your body, skin, muscle, bone, teeth, all organs, pituitary, adrenals, heart, kidney, liver, ovaries, testes, and your brain, contain and require vitamin C." Unfortunately your tissue levels cannot be tested until you're dead. You need to take vit C and experiment for the best dosage for you.

Kuhn Thomas S., "The Structure of Scientific Revolutions," Philosopher's Web Magazine, Kuhn: Scientific revolutions

Kuhn's central claim is that a careful study of the history of science reveals that development in any scientific field happens via a series of phases. "Normal science does not aim at novelty but at clearing up the status quo. It tends to discover what it expects to discover." Scientific revolution occurs when the previous paradigm of a scientific discipline is completely overthrown by a new paradigm.

Laibow Rima E., "Nutrition and Health," Natural Solutions Foundation,   Laibow: nutrition & health

Biochemical Individuality is made up of: 1. Genetic factors/family history 2. Digestive capacities 3. Absorbtive capacities 4. Toxic load 5. Heavy metal or other enzyme inhibitors 6. Underlying disease 7. Adrenal status 8. Immune competence and status 9. Acid-Base balance 10. Enzyme production 11. Lymphatic efficiency 12. Mineralization of bone 13. Hormone status 14. Age 15. Gender 16. Life cycle stage 17. Dietary intake 18. Treatment with drugs, radiation 19. Emotional status 20. Vaccination status 21. Gut ecology 22. Etc.

Marler John B. and Jeanne R. Wallin, "Human Health, the Nutritional Quality of Harvested Food and Sustainable Farming Systems,"Nutrition Security Institute, U.S. Senate Document 264 1936. 2006.  Marler nutri values from soils 2006

Messina Ginny, "Understanding Nutrition Research: A Quick Primer," The Vegan R.D., June 8, 2011.   Messina: nutrition research 2011

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Minerals: "Nutrients and Health/Disease,"  Minerals

Moosa Tauriq, "How Shoddy Medical Research Can Harm Us All," Think Big, September 25, 2012.   Moosa: Shody med research 2012

Moyer Melinda Wenner, "It's Time to End the War on Salt," Scientific American, July 8, 2011.   Moyer: end salt war 2011 quot;The zealous drive by politicians to limit our salt intake has little basis in science."

Myslewski Rik, "Chip daddy Mead: 'A bunch of big egos' are strangling science," Science, February 20, 2013.   Myslewski: science stalled 2013  "The scientific revolution has stalled.

" O’Shea Tim, "Minerals," The Doctor Within. Commercial attachment but content is good.  O'Shea: Minerals

Patton Richard, "EFFICACY OF CHELATED MINERALS; REVIEW OF LITERATURE."  Patton: Chelated minerals review

Prentice Ross L. and others, "Nutrition and Physical Activity and Chronic Disease Prevention: Research Strategies and Recommendations," JNCI J Natl Cancer Inst, June 28, 2004, Volume 96, Issue 17, Pp. 1276-1287.   Prentice: Nutrition & cancer 2004

Real Food Forager, "Salt Reduction: The Largest Delusion in Public Health History," Real Food Forager, March 29, 2012.  Real Food Forager: salt delusion 2012

Recommended Daily Intake (RDI) is the daily intake level of a nutrient that is considered to be sufficient to meet the requirements of 97–98% of healthy individuals in every demographic in the United States (where it was developed, but has since been used in other places).

Robinson Arthur, "How Government Corrupts Science," Science and Public Policy Institute, March 16, 2010.  Robinson: Govt corrupts science 2010

Rollins Gina, "Vitamin D testing -- What's the right answer," Clinical Lab news, American Association for Clinical Chemistry. July, 2009 Volume 35 Number 7. Rollins Vit D testing

Schachter Michael B., "Iodine: Its Role In Health and Disease - Some New Exciting Concepts," Schachter Center for Complementary Medicine, August 7, 2005.Schachter: Iodine role

Scurvy often presents itself initially as symptoms of malaise and lethargy, followed by formation of spots on the skin, spongy gums, and bleeding from the mucous membranes. Spots are most abundant on the thighs and legs, and a person with the ailment looks pale, feels depressed, and is partially immobilized. As scurvy advances, there can be open, suppurating wounds, loss of teeth, jaundice, fever, neuropathy and death. Vitamin C  is required for the synthesis of collagen in humans; collagen is the glue that binds body tissues together. 

SandstroÈm Brittmarie, "Micronutrient interactions: effects on absorption and bioavailability," British Journal of Nutrition (2001), 85, Suppl. 2, S181±S185. nbsp; SandstroÈm: Micronutrient interactions 2001

Salt Institute, "Evidence-Based Public Health: More than a Platitude," alt and Health Newsletter, 2006 Speing, Vol. 1 No. 2.  Salt Institute: 2006

Schroeder J.W., "Use of minerals in dairy cattle feed," June 2012.  Schroeder: Minerals in cattle 2012

Shao Andrew, "Evidence-Based Nutrition," The World of Food Ingredients, October/November, 2009.  Shao: evidence nutrition 2009

drugs-nutrient contrast
Shao: evidence nutrition 2009

Synergistically Balanced Amino Acid Chelated Minerals, Senerex,  Senerex:

Taubes Gary "Do We Really Know What Makes Us Healthy?" The New York Times magazine, September 16, 2007.  Taubes: epidemiological studies on health 2007

"The case of hormone-replacement therapy for post-menopausal women is just one of the cautionary tales in the annals of epidemiology. It’s a particularly glaring example of the difficulties of trying to establish reliable knowledge in any scientific field with research tools that themselves may be unreliable. In 1985, the Nurses’ Health Study run out of the Harvard Medical School and the Harvard School of Public Health  gathered information about hormone-replacement therapy, or H.R.T., from 122,000 nurses.  In these studies, the investigators monitor disease rates and lifestyle factors (diet, physical activity, prescription drug use, exposure to pollutants, etc.) in or between large populations. They then try to infer conclusions — i.e., hypotheses — about what caused the disease variations observed. "

The RDI is used to determine the Daily Value (DV) of foods, which is printed on nutrition facts labels in the a title="United States" href="http://en.wikipedia.org/wiki/United_States">United States and Canada, which is regulated by the Food and Drug Administration (FDA), and a title="Health Canada" href="http://en.wikipedia.org/wiki/Health_Canada">Health Canada.

The RDI is based on the older Recommended Dietary Allowance (RDA) from 1968;  newer RDAs have since been introduced in the title="Dietary Reference Intake" href="http://en.wikipedia.org/wiki/Dietary_Reference_Intake">Dietary Reference Intake system, but the RDI is still used for nutrition labeling.

Union of Concerned Scientists, "How Corporations Corrupt Science at the Public's Expense," Scientific Integrity, February 16, 2012.  Scientific Integrity 2012

"Vitamin C controversy," Clin J Pain, Volume 26, Number 6, July/August 2010.   Vit C controversy 2010

Vitamin D Council, "Am I vitamin D deficient?" January 10, 2008. Vit D Council Min dosage

Whiting Steven E., "Mineral Interactions and Absorption fact sheet," [How minerals are absorbed in the human body], October 17, 2009.  Whiting: Mineral absorption 2009

Wikipedia, "Biochemistry."   Wiki: biochemistry

Wikipedia, ”Cofactor (biochemistry),"  wiki Cofactor_(biochemistry)

Wikipedia, "Dietary Reference Intake." September 2, 2012.   Wiki: Diet Ref Intake 2012

Wikipedia, "Metalloprotein."   Wiki: metalloprotein 

Wikipedia, "Reference Daily Intake," BioScience.  Wiki: RDI   

Wikipedia, "Reference Daily Intake,  Wiki: RDI

Recommended Daily Intake (RDI) is the daily intake level of a nutrient that is considered to be sufficient to meet the requirements of 97–98% of healthy individuals in every demographic in the United States (where it was developed, but has since been used in other places).

The RDI is used to determine the Daily Value (DV) of foods, which is printed on nutrition facts labels in the United States and Canada, which is regulated by the Food and Drug Administration (FDA), and Health Canada.

The RDI is based on the older Recommended Dietary Allowance (RDA) from 1968; newer RDAs have since been introduced in the Dietary Reference Intake system, but the RDI is still used for nutrition labeling.